1k8k

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[[Image:1k8k.gif|left|200px]]<br /><applet load="1k8k" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1k8k.gif|left|200px]]
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caption="1k8k, resolution 2.0&Aring;" />
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'''Crystal Structure of Arp2/3 Complex'''<br />
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{{Structure
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|PDB= 1k8k |SIZE=350|CAPTION= <scene name='initialview01'>1k8k</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal Structure of Arp2/3 Complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1K8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8K OCA].
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1K8K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8K OCA].
==Reference==
==Reference==
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Crystal structure of Arp2/3 complex., Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD, Science. 2001 Nov 23;294(5547):1679-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11721045 11721045]
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Crystal structure of Arp2/3 complex., Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD, Science. 2001 Nov 23;294(5547):1679-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11721045 11721045]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: beta-propeller]]
[[Category: beta-propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:57 2008''

Revision as of 10:14, 20 March 2008

Image:1k8k.gif


PDB ID 1k8k

Drag the structure with the mouse to rotate
, resolution 2.0Å
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Arp2/3 Complex


Overview

We determined a crystal structure of bovine Arp2/3 complex, an assembly of seven proteins that initiates actin polymerization in eukaryotic cells, at 2.0 angstrom resolution. Actin-related protein 2 (Arp2) and Arp3 are folded like actin, with distinctive surface features. Subunits ARPC2 p34 and ARPC4 p20 in the core of the complex associate through long carboxyl-terminal alpha helices and have similarly folded amino-terminal alpha/beta domains. ARPC1 p40 is a seven-blade beta propeller with an insertion that may associate with the side of an actin filament. ARPC3 p21 and ARPC5 p16 are globular alpha-helical subunits. We predict that WASp/Scar proteins activate Arp2/3 complex by bringing Arp2 into proximity with Arp3 for nucleation of a branch on the side of a preexisting actin filament.

About this Structure

1K8K is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Arp2/3 complex., Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD, Science. 2001 Nov 23;294(5547):1679-84. PMID:11721045

Page seeded by OCA on Thu Mar 20 12:13:57 2008

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