4o0a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4o0a| PDB=4o0a | SCENE= }}
+
==Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions==
-
===Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions===
+
<StructureSection load='4o0a' size='340' side='right' caption='[[4o0a]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4o0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O0A FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P9:5-{4-[({[4-(5-CARBOXYFURAN-2-YL)-2-CHLOROPHENYL]CARBONOTHIOYL}AMINO)METHYL]PHENYL}-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>2P9</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4luv|4luv]], [[4lwc|4lwc]], [[4lwi|4lwi]], [[4luz|4luz]], [[4luo|4luo]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o0a RCSB], [http://www.ebi.ac.uk/pdbsum/4o0a PDBsum]</span></td></tr>
 +
</table>
-
==Function==
+
==See Also==
-
[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
+
*[[Single-stranded DNA-binding protein|Single-stranded DNA-binding protein]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[4o0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA].
+
-
 
+
-
==Reference==
+
-
<references group="xtra"/><references/>
+
[[Category: Camper, D V.]]
[[Category: Camper, D V.]]
[[Category: Chazin, W J.]]
[[Category: Chazin, W J.]]
[[Category: Feldkamp, M D.]]
[[Category: Feldkamp, M D.]]
[[Category: Fesik, S W.]]
[[Category: Fesik, S W.]]
-
[[Category: Frank, A O]]
+
[[Category: Frank, A O.]]
[[Category: Kennedy, J P.]]
[[Category: Kennedy, J P.]]
[[Category: Olejniczak, E T.]]
[[Category: Olejniczak, E T.]]

Revision as of 07:03, 5 November 2014

Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions

4o0a, resolution 1.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4o0a"
Personal tools