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4o0a

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{{STRUCTURE_4o0a| PDB=4o0a | SCENE= }}
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==Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions==
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===Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions===
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<StructureSection load='4o0a' size='340' side='right' caption='[[4o0a]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4o0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O0A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P9:5-{4-[({[4-(5-CARBOXYFURAN-2-YL)-2-CHLOROPHENYL]CARBONOTHIOYL}AMINO)METHYL]PHENYL}-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>2P9</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4luv|4luv]], [[4lwc|4lwc]], [[4lwi|4lwi]], [[4luz|4luz]], [[4luo|4luo]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o0a RCSB], [http://www.ebi.ac.uk/pdbsum/4o0a PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
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*[[Single-stranded DNA-binding protein|Single-stranded DNA-binding protein]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4o0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Camper, D V.]]
[[Category: Camper, D V.]]
[[Category: Chazin, W J.]]
[[Category: Chazin, W J.]]
[[Category: Feldkamp, M D.]]
[[Category: Feldkamp, M D.]]
[[Category: Fesik, S W.]]
[[Category: Fesik, S W.]]
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[[Category: Frank, A O]]
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[[Category: Frank, A O.]]
[[Category: Kennedy, J P.]]
[[Category: Kennedy, J P.]]
[[Category: Olejniczak, E T.]]
[[Category: Olejniczak, E T.]]

Revision as of 07:03, 5 November 2014

Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions

4o0a, resolution 1.20Å

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