1k9j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k9j.jpg|left|200px]]<br /><applet load="1k9j" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1k9j.jpg|left|200px]]
-
caption="1k9j, resolution 1.90&Aring;" />
+
 
-
'''Complex of DC-SIGNR and GlcNAc2Man3'''<br />
+
{{Structure
 +
|PDB= 1k9j |SIZE=350|CAPTION= <scene name='initialview01'>1k9j</scene>, resolution 1.90&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''Complex of DC-SIGNR and GlcNAc2Man3'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
1K9J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9J OCA].
+
1K9J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9J OCA].
==Reference==
==Reference==
-
Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR., Feinberg H, Mitchell DA, Drickamer K, Weis WI, Science. 2001 Dec 7;294(5549):2163-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11739956 11739956]
+
Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR., Feinberg H, Mitchell DA, Drickamer K, Weis WI, Science. 2001 Dec 7;294(5549):2163-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11739956 11739956]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 24: Line 33:
[[Category: protein carbohydrate complex]]
[[Category: protein carbohydrate complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:38 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:14:28 2008''

Revision as of 10:14, 20 March 2008

Image:1k9j.jpg


PDB ID 1k9j

Drag the structure with the mouse to rotate
, resolution 1.90Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Complex of DC-SIGNR and GlcNAc2Man3


Contents

Overview

Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.

Disease

Known disease associated with this structure: SARS infection, protection against OMIM:[605872]

About this Structure

1K9J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR., Feinberg H, Mitchell DA, Drickamer K, Weis WI, Science. 2001 Dec 7;294(5549):2163-6. PMID:11739956

Page seeded by OCA on Thu Mar 20 12:14:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k9j"
Personal tools