4u4i
From Proteopedia
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| - | ''' | + | ==Megavirus chilensis superoxide dismutase== |
| + | <StructureSection load='4u4i' size='340' side='right' caption='[[4u4i]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4u4i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4I FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4i RCSB], [http://www.ebi.ac.uk/pdbsum/4u4i PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Megavirus chilensis, a close relative of the Mimivirus giant virus, is able to replicate in Acanthamoeba castellanii. The first step of viral infection involves the internalization of the virions in host vacuoles. It has been experimentally demonstrated that Mimivirus particles contain many proteins capable of resisting oxidative stress, as encountered in the phagocytic process. These proteins are conserved in Megavirus, which has an additional gene (Mg277) encoding a putative superoxide dismutase. The Mg277 ORF product was overexpressed in Escherichia coli, purified and crystallized. A SAD data set was collected to 2.24 A resolution at the selenium peak wavelength on the BM30 beamline at the ESRF from a single crystal of selenomethionine-substituted recombinant superoxide dismutase protein. | ||
| - | + | Preliminary crystallographic analysis of the Megavirus superoxide dismutase.,Lartigue A, Philippe N, Jeudy S, Abergel C Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1557-9., doi: 10.1107/S174430911204657X. Epub 2012 Nov 28. PMID:23192047<ref>PMID:23192047</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Superoxide dismutase]] | ||
| + | [[Category: Abergel, C.]] | ||
| + | [[Category: Burlat, B.]] | ||
| + | [[Category: Claverie, J M.]] | ||
| + | [[Category: Coutard, B.]] | ||
| + | [[Category: Lartigue, A.]] | ||
| + | [[Category: Cu-zn superoxide dismutase]] | ||
| + | [[Category: Metal-free]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 08:43, 5 November 2014
Megavirus chilensis superoxide dismutase
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