3c6d

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[[Image:3c6d.png|left|200px]]
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==The pseudo-atomic structure of dengue immature virus==
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<StructureSection load='3c6d' size='340' side='right' caption='[[3c6d]], [[Resolution|resolution]] 12.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3c6d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Dengue_virus_2_thailand/16681/84 Dengue virus 2 thailand/16681/84]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C6D FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c5x|3c5x]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c6d RCSB], [http://www.ebi.ac.uk/pdbsum/3c6d PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the proteolytic cleavage of the precursor membrane protein (prM), turning inert virus into infectious particles. We have determined the 2.2 angstrom resolution crystal structure of a recombinant protein in which the dengue virus prM is linked to the envelope glycoprotein E. The structure represents the prM-E heterodimer and fits well into the cryo-electron microscopy density of immature virus at neutral pH. The pr peptide beta-barrel structure covers the fusion loop in E, preventing fusion with host cell membranes. The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host.
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{{STRUCTURE_3c6d| PDB=3c6d | SCENE= }}
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The flavivirus precursor membrane-envelope protein complex: structure and maturation.,Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG Science. 2008 Mar 28;319(5871):1830-4. PMID:18369147<ref>PMID:18369147</ref>
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===The pseudo-atomic structure of dengue immature virus===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18369147}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3c6d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6D OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018369147</ref><references group="xtra"/>
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
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[[Category: Viruses]]
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[[Category: Dengue virus 2 thailand/16681/84]]
[[Category: Li, L.]]
[[Category: Li, L.]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]

Revision as of 09:19, 5 November 2014

The pseudo-atomic structure of dengue immature virus

3c6d, resolution 12.50Å

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