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2kqh

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[[Image:2kqh.png|left|200px]]
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==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==
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<StructureSection load='2kqh' size='340' side='right' caption='[[2kqh]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KQH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kqg|2kqg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has been recently identified in the promoter region of the c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble of structures that share the same parallel-stranded propeller-type conformations. Subtle differences in structural dynamics have been identified using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting the coexistence of at least two structurally similar but dynamically distinct substates, which undergo slow interconversion on the NMR timescale.
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{{STRUCTURE_2kqh| PDB=2kqh | SCENE= }}
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A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.,Hsu ST, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S J Am Chem Soc. 2009 Sep 23;131(37):13399-409. PMID:19705869<ref>PMID:19705869</ref>
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===A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19705869}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019705869</ref><ref group="xtra">PMID:016784237</ref><references group="xtra"/>
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[[Category: Balasubramanian, S.]]
[[Category: Balasubramanian, S.]]
[[Category: Bugaut, A.]]
[[Category: Bugaut, A.]]

Revision as of 09:23, 5 November 2014

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics

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