2w1b

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[[Image:2w1b.png|left|200px]]
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==THE STRUCTURE OF THE EFFLUX PUMP ACRB IN COMPLEX WITH BILE ACID==
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<StructureSection load='2w1b' size='340' side='right' caption='[[2w1b]], [[Resolution|resolution]] 3.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W1B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1oy8|1oy8]], [[1t9u|1t9u]], [[1iwg|1iwg]], [[1t9t|1t9t]], [[1t9y|1t9y]], [[1t9w|1t9w]], [[2j8s|2j8s]], [[1oy6|1oy6]], [[1t9x|1t9x]], [[2gif|2gif]], [[2hrt|2hrt]], [[1oye|1oye]], [[1oyd|1oyd]], [[1oy9|1oy9]], [[1t9v|1t9v]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w1b RCSB], [http://www.ebi.ac.uk/pdbsum/2w1b PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.
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{{STRUCTURE_2w1b| PDB=2w1b | SCENE= }}
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The structure of the efflux pump AcrB in complex with bile acid.,Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K Mol Membr Biol. 2008 Dec;25(8):677-82. PMID:19023693<ref>PMID:19023693</ref>
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===THE STRUCTURE OF THE EFFLUX PUMP ACRB IN COMPLEX WITH BILE ACID===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19023693}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2w1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1B OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019023693</ref><ref group="xtra">PMID:012374972</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Beis, K.]]
[[Category: Beis, K.]]

Revision as of 09:24, 5 November 2014

THE STRUCTURE OF THE EFFLUX PUMP ACRB IN COMPLEX WITH BILE ACID

2w1b, resolution 3.85Å

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