2pl8

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[[Image:2pl8.png|left|200px]]
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==D(GTATACC) under hydrostatic pressure of 1.04 GPa==
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<StructureSection load='2pl8' size='340' side='right' caption='[[2pl8]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2pl8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PL8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[115d|115d]], [[1vj4|1vj4]], [[2pkv|2pkv]], [[2pl4|2pl4]], [[2plb|2plb]], [[2plo|2plo]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pl8 RCSB], [http://www.ebi.ac.uk/pdbsum/2pl8 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
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{{STRUCTURE_2pl8| PDB=2pl8 | SCENE= }}
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Adaptation of the base-paired double-helix molecular architecture to extreme pressure.,Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642<ref>PMID:17617642</ref>
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===D(GTATACC) under hydrostatic pressure of 1.04 GPa===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17617642}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2pl8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PL8 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017617642</ref><ref group="xtra">PMID:002911354</ref><ref group="xtra">PMID:011524565</ref><ref group="xtra">PMID:016478683</ref><references group="xtra"/>
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[[Category: Fourme, R.]]
[[Category: Fourme, R.]]
[[Category: Girard, E.]]
[[Category: Girard, E.]]

Revision as of 09:31, 5 November 2014

D(GTATACC) under hydrostatic pressure of 1.04 GPa

2pl8, resolution 1.65Å

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