Telomerase 3D structures

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Revision as of 04:31, 6 November 2014

Image:Tert.png
Structure of the catalytic subunit of telomerase, TERT, 3du5

Template:STRUCTURE 2r4g










Telomerase (TEL) adds DNA repeats to the tail end of telomeres. It carries its own RNA. The human TEL is composed of 2 Telomerase Reverse Transcriptase (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. For additional details see Catalytic Subunit of T. Castaneum TERT Polymerase.

Contents

3D Structures of Telomerase


3kyl, 3du5, 3du6 – TERT+DNA – Tribolium castaneum
2r4g – TtTERT RNA binding domain – Tetrahymena thermophila
2b2a – TtTERT (mutant)
2fey - TtTERC RNA P2b hairpin – NMR
1q75, 2k96 – hTERC RNA P2b hairpin (mutant) – human – NMR
2k95 - hTERC RNA P2b hairpin – NMR
2qh2 - hTERC RNA CR7– NMR
1na2, 1ymo - hTERC RNAstem loop IV– NMR
1z31 - hTERC RNA Pj6 hairpin – NMR

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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