1kfr

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[[Image:1kfr.jpg|left|200px]]<br /><applet load="1kfr" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1kfr.jpg|left|200px]]
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caption="1kfr, resolution 1.85&Aring;" />
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'''Structural plasticity in the eight-helix fold of a trematode hemoglobin'''<br />
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{{Structure
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|PDB= 1kfr |SIZE=350|CAPTION= <scene name='initialview01'>1kfr</scene>, resolution 1.85&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structural plasticity in the eight-helix fold of a trematode hemoglobin'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1KFR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Paramphistomum_epiclitum Paramphistomum epiclitum] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFR OCA].
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1KFR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Paramphistomum_epiclitum Paramphistomum epiclitum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFR OCA].
==Reference==
==Reference==
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Structural plasticity in the eight-helix fold of a trematode haemoglobin., Milani M, Pesce A, Dewilde S, Ascenzi P, Moens L, Bolognesi M, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):719-22. Epub 2002, Mar 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11914507 11914507]
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Structural plasticity in the eight-helix fold of a trematode haemoglobin., Milani M, Pesce A, Dewilde S, Ascenzi P, Moens L, Bolognesi M, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):719-22. Epub 2002, Mar 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11914507 11914507]
[[Category: Paramphistomum epiclitum]]
[[Category: Paramphistomum epiclitum]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hemoglobin]]
[[Category: hemoglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:33:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:16:53 2008''

Revision as of 10:16, 20 March 2008

Image:1kfr.jpg


PDB ID 1kfr

Drag the structure with the mouse to rotate
, resolution 1.85Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Structural plasticity in the eight-helix fold of a trematode hemoglobin


Overview

The three-dimensional structure of recombinant haemoglobin from the trematode Paramphistomum epiclitum, displaying the highest oxygen affinity so far observed for (non)vertebrate haemoglobins, has previously been determined at 1.17 A resolution (orthorhombic space group P2(1)2(1)2(1)). In the present communication, the three-dimensional structure of wild-type P. epiclitum haemoglobin is reported at 1.85 A resolution in a monoclinic crystal form (R factor = 16.1%, R(free) = 22.0%). Comparison of P. epiclitum (recombinant versus wild-type ferric Hb) structures in the two crystal forms shows structural differences in the haem proximal and distal sites which have not been reported for other known haemoglobin structures previously.

About this Structure

1KFR is a Single protein structure of sequence from Paramphistomum epiclitum. Full crystallographic information is available from OCA.

Reference

Structural plasticity in the eight-helix fold of a trematode haemoglobin., Milani M, Pesce A, Dewilde S, Ascenzi P, Moens L, Bolognesi M, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):719-22. Epub 2002, Mar 22. PMID:11914507

Page seeded by OCA on Thu Mar 20 12:16:53 2008

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