1kil
From Proteopedia
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| - | [[Image:1kil.gif|left|200px]] | + | [[Image:1kil.gif|left|200px]] |
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| - | '''Three-dimensional structure of the complexin/SNARE complex''' | + | {{Structure |
| + | |PDB= 1kil |SIZE=350|CAPTION= <scene name='initialview01'>1kil</scene>, resolution 2.30Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= Synaptobrevin 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Syntaxin 1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), SNAP-25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Complexin 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | }} | ||
| + | |||
| + | '''Three-dimensional structure of the complexin/SNARE complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KIL is a [ | + | 1KIL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIL OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional structure of the complexin/SNARE complex., Chen X, Tomchick DR, Kovrigin E, Arac D, Machius M, Sudhof TC, Rizo J, Neuron. 2002 Jan 31;33(3):397-409. PMID:[http:// | + | Three-dimensional structure of the complexin/SNARE complex., Chen X, Tomchick DR, Kovrigin E, Arac D, Machius M, Sudhof TC, Rizo J, Neuron. 2002 Jan 31;33(3):397-409. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11832227 11832227] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: helix bound to four helix bundle]] | [[Category: helix bound to four helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:17:56 2008'' |
Revision as of 10:17, 20 March 2008
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| , resolution 2.30Å | |||||||
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| Ligands: | |||||||
| Gene: | Synaptobrevin 2 (Rattus norvegicus), Syntaxin 1A (Rattus norvegicus), SNAP-25 (Homo sapiens), Complexin 1 (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Three-dimensional structure of the complexin/SNARE complex
Overview
During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca(2+)-evoked neurotransmitter release. A combined X-ray and TROSY-based NMR study now reveals the atomic structure of the complexin/SNARE complex. Complexin binds in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. This interaction stabilizes the interface between these two helices, which bears the repulsive forces between the apposed membranes. These results suggest that complexin stabilizes the fully assembled SNARE complex as a key step that enables the exquisitely high speed of Ca(2+)-evoked neurotransmitter release.
About this Structure
1KIL is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the complexin/SNARE complex., Chen X, Tomchick DR, Kovrigin E, Arac D, Machius M, Sudhof TC, Rizo J, Neuron. 2002 Jan 31;33(3):397-409. PMID:11832227
Page seeded by OCA on Thu Mar 20 12:17:56 2008
