1kke
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1kke.gif|left|200px]] | + | [[Image:1kke.gif|left|200px]] |
| - | + | ||
| - | '''Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer''' | + | {{Structure |
| + | |PDB= 1kke |SIZE=350|CAPTION= <scene name='initialview01'>1kke</scene>, resolution 2.6Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1KKE is a [ | + | 1KKE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKE OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber., Chappell JD, Prota AE, Dermody TS, Stehle T, EMBO J. 2002 Jan 15;21(1-2):1-11. PMID:[http:// | + | Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber., Chappell JD, Prota AE, Dermody TS, Stehle T, EMBO J. 2002 Jan 15;21(1-2):1-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11782420 11782420] |
[[Category: Reovirus sp.]] | [[Category: Reovirus sp.]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 25: | Line 34: | ||
[[Category: trimer]] | [[Category: trimer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:18:36 2008'' |
Revision as of 10:18, 20 March 2008
| |||||||
| , resolution 2.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer
Overview
Reovirus attaches to cellular receptors with the sigma1 protein, a fiber-like molecule protruding from the 12 vertices of the icosahedral virion. The crystal structure of a receptor-binding fragment of sigma1 reveals an elongated trimer with two domains: a compact head with a new beta-barrel fold and a fibrous tail containing a triple beta-spiral. Numerous structural and functional similarities between reovirus sigma1 and the adenovirus fiber suggest an evolutionary link in the receptor-binding strategies of these two viruses. A prominent loop in the sigma1 head contains a cluster of residues that are conserved among reovirus serotypes and are likely to form a binding site for junction adhesion molecule, an integral tight junction protein that serves as a reovirus receptor. The fibrous tail is mainly responsible for sigma1 trimer formation, and it contains a highly flexible region that allows for significant movement between the base of the tail and the head. The architecture of the trimer interface and the observed flexibility indicate that sigma1 is a metastable structure poised to undergo conformational changes upon viral attachment and cell entry.
About this Structure
1KKE is a Single protein structure of sequence from Reovirus sp.. Full crystallographic information is available from OCA.
Reference
Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber., Chappell JD, Prota AE, Dermody TS, Stehle T, EMBO J. 2002 Jan 15;21(1-2):1-11. PMID:11782420
Page seeded by OCA on Thu Mar 20 12:18:36 2008
Categories: Reovirus sp. | Single protein | Chappell, J D. | Dermody, T S. | Prota, A E. | Stehle, T. | Beta-barrel | Beta-spiral | Fiber | Receptor-binding | Reovirus | Sigma1 | Trimer
