Acetyl-CoA synthase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 7: Line 7:
-->
-->
'''Acetyl-CoA synthase''' (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes. ACS-I catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons. ACS-II catalyzes the reverse reaction. ACS-III uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA. ACS-IV catabolizes CO to CO2. ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer. ACS can form a bifunctional entity with carbon monoxide dehydrogenase (CODH).
'''Acetyl-CoA synthase''' (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes. ACS-I catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons. ACS-II catalyzes the reverse reaction. ACS-III uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA. ACS-IV catabolizes CO to CO2. ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer. ACS can form a bifunctional entity with carbon monoxide dehydrogenase (CODH).
 +
 +
</StructureSection>
==3D structures of acetyl-CoA synthase==
==3D structures of acetyl-CoA synthase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
 +
 +
*CODH/ACS bifunctional entity
-
'''CODH/ACS bifunctional entity'''
+
**[[1mjg]], [[1oao]], [[2z8y]], [[3i01]] – MtACS α+β + Fe4-Ni-S4 – ''Moorella thermoacetica''<br />
 +
**[[3i04]] - MtACS α+β + CN + Fe4-Ni-S4<br />
 +
**[[3git]] - MtACS α + Fe4S4<br />
 +
**[[3s2x]] - MtACS α C terminal + Ni<br />
 +
**[[2h9a]] – ChACS γ + Fe4S4 - ''Carboxydothermus hydrogenoformans''<br />
 +
**[[2ycl]] - ChACS γ + cobalamine + Fe4S4<br />
-
[[1mjg]], [[1oao]], [[2z8y]], [[3i01]] – MtACS α+β + Fe4-Ni-S4 – ''Moorella thermoacetica''<br />
+
*ACS
-
[[3i04]] - MtACS α+β + CN + Fe4-Ni-S4<br />
+
-
[[3git]] - MtACS α + Fe4S4<br />
+
-
[[3s2x]] - MtACS α C terminal + Ni<br />
+
-
[[2h9a]] – ChACS γ + Fe4S4 - ''Carboxydothermus hydrogenoformans''<br />
+
-
[[2ycl]] - ChACS γ + cobalamine + Fe4S4<br />
+
-
'''ACS'''
+
**[[1ytl]] – ACS ε – ''Archaeoglobus fulgidus''<br />
 +
**[[3cf4]] - ACS α+ε + CO + Fe3-Ni-S4 + Fe4S4 – ''Methanosarcina barkeri''
-
[[1ytl]] – ACS ε – ''Archaeoglobus fulgidus''<br />
+
*ACS-IV
-
[[3cf4]] - ACS α+ε + CO + Fe3-Ni-S4 + Fe4S4 – ''Methanosarcina barkeri''
+
-
'''ACS-IV'''
+
**[[1ru3]] - ChACS α + Fe4-Ni-S4
-
[[1ru3]] - ChACS α + Fe4-Ni-S4
+
}}

Revision as of 14:04, 11 November 2014

Template:STRUCTURE 1ru3

Acetyl-CoA synthase (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes. ACS-I catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons. ACS-II catalyzes the reverse reaction. ACS-III uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA. ACS-IV catabolizes CO to CO2. ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer. ACS can form a bifunctional entity with carbon monoxide dehydrogenase (CODH).

</StructureSection>

3D structures of acetyl-CoA synthase

Updated on 11-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Acetyl-CoA_synthase"
Personal tools