Acetylcholine binding protein

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{{STRUCTURE_2byn| PDB=2byn | SIZE=400| SCENE=Acetylcholine_binding_protein/Cv/1 |right|CAPTION=Acetylcholine binding protein pentamer complex with PEG [[2byn]] }}
{{STRUCTURE_2byn| PDB=2byn | SIZE=400| SCENE=Acetylcholine_binding_protein/Cv/1 |right|CAPTION=Acetylcholine binding protein pentamer complex with PEG [[2byn]] }}
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<br />
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</StructureSection>
== 3D Structures of Acetylcholine binding protein ==
== 3D Structures of Acetylcholine binding protein ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== AChBP - Apo proteins ===
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* AChBP - Apo proteins
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[[2w8e]], [[2byn]], [[2y7y]] - ''Aplysia californica'' (AcAChBP) <br />
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**[[2w8e]], [[2byn]], [[2y7y]] - ''Aplysia californica'' (AcAChBP) <br />
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[[2xz6]], [[3sh1]], [[3sio]], [[3t4m]] – AcAChBP (mutant)<br />
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**[[2xz6]], [[3sh1]], [[3sio]], [[3t4m]] – AcAChBP (mutant)<br />
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[[1ux2]], [[1i9b]] - ''Lymnaea stagnalis'' (LsAChBP) <br />
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**[[1ux2]], [[1i9b]] - ''Lymnaea stagnalis'' (LsAChBP) <br />
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[[2bj0]] - ''Bulinus truncatus''<br />
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**[[2bj0]] - ''Bulinus truncatus''<br />
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[[4aod]], [[4aoe]] – AchBP – Cryo EM – ''Biomphalaria glabrata''<br />
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**[[4aod]], [[4aoe]] – AchBP – Cryo EM – ''Biomphalaria glabrata''<br />
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=== AChBP + marine biotoxins ===
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* AChBP + marine biotoxins
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[[2wzy]] - AcAChBP + 13-desmethyl spirolide C <br />
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**[[2wzy]] - AcAChBP + 13-desmethyl spirolide C <br />
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[[2x00]] - AcAChBP + gymnodimine A <br />
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**[[2x00]] - AcAChBP + gymnodimine A <br />
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=== AChBP + partial agonists; Activate the receptor with partial efficacy ===
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* AChBP + partial agonists; Activate the receptor with partial efficacy
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[[2wn9]] - AcAChBP + 4-OH-DMXBA <br />
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**[2wn9]] - AcAChBP + 4-OH-DMXBA <br />
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[[2wnc]] - AcAChBP + tropisetron <br />
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**[[2wnc]] - AcAChBP + tropisetron <br />
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[[2wnj]] - AcAChBP + DMXBA <br />
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**[[2wnj]] - AcAChBP + DMXBA <br />
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[[2wnl]] - AcAChBP + anabaseine <br />
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**[[2wnl]] - AcAChBP + anabaseine <br />
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[[3u8j]], [[3u8k]], [[3u8l]], [[3u8n]] – LsAChBP + agonist<br />
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**[[3u8j]], [[3u8k]], [[3u8l]], [[3u8n]] – LsAChBP + agonist<br />
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=== AChBP+ions; Mimicking the ion conductance of the receptor ===
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* AChBP+ions; Mimicking the ion conductance of the receptor
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[[3gua]] - AcAChBP + sulfate <br />
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**[[3gua]] - AcAChBP + sulfate <br />
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=== AChBP+ neonicotinoids; Insecticides with lower affinity to mammals ===
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* AChBP+ neonicotinoids; Insecticides with lower affinity to mammals
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[[3c79]] - AcAChBP + imidacloprid <br />
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**[[3c79]] - AcAChBP + imidacloprid <br />
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[[2zju]] - LsAChBP + imidacloprid <br />
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**[[2zju]] - LsAChBP + imidacloprid <br />
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[[3c84]] - AcAChBP + thiacloprid <br />
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**[[3c84]] - AcAChBP + thiacloprid <br />
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[[2zjv]] - LsAChBP+clothianidin <br />
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**[[2zjv]] - LsAChBP+clothianidin <br />
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=== AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction ===
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* AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction
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[[2pjz]] - AcAChBP+cocaine <br />
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**[[2pjz]] - AcAChBP+cocaine <br />
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[[2ph9]] - AcAChBP+galanthamine <br />
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**[[2ph9]] - AcAChBP+galanthamine <br />
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[[2w8f]], [[2w8g]] - AcAChBP + in silico compounds <br />
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**[[2w8f]], [[2w8g]] - AcAChBP + in silico compounds <br />
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[[4alx]], [[4bfq]] – AcAChBP + antagonist<br />
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**[[4alx]], [[4bfq]] – AcAChBP + antagonist<br />
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=== AChBP+ peptide inhibitors ===
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* AChBP+ peptide inhibitors
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[[2c9t]], [[2byp]], [[2br8]] - AcAChBP+conotoxin IMI <br />
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**[[2c9t]], [[2byp]], [[2br8]] - AcAChBP+conotoxin IMI <br />
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[[2uz6]] – AcAChBP fragment + α-conotoxin<br />
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**[[2uz6]] – AcAChBP fragment + α-conotoxin<br />
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[[1yi5]] - AcAChBP+cobratoxin <br />
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**[[1yi5]] - AcAChBP+cobratoxin <br />
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=== AChBP+ nicotinic agonists enhance the action of the nAChR ===
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* AChBP+ nicotinic agonists enhance the action of the nAChR
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[[2pgz]] - AcAChBP+cocaine <br />
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**[[2pgz]] - AcAChBP+cocaine <br />
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[[2byr]] - AcAChBP+methyllycaconitine <br />
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**[[2byr]] - AcAChBP+methyllycaconitine <br />
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[[2bys]] - AcAChBP+lobeline <br />
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**[[2bys]] - AcAChBP+lobeline <br />
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[[2xnt]], [[2xnu]], [[2xnv]] – AcAChBP + ligand<br />
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**[[2xnt]], [[2xnu]], [[2xnv]] – AcAChBP + ligand<br />
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[[3peo]] - AcAChBP+metocurine<br />
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**[[3peo]] - AcAChBP+metocurine<br />
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[[3pmz]] - AcAChBP+tubocurarine<br />
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**[[3pmz]] - AcAChBP+tubocurarine<br />
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[[2byq]] - AcAChBP+epibatidine
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**[[2byq]] - AcAChBP+epibatidine
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=== AChBP+ ligand homologs of the ligand acetylcholine ===
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* AChBP+ ligand homologs of the ligand acetylcholine
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[[1uv6]] - LsAChBP+ carbamylcholine <br />
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**[[1uv6]] - LsAChBP+ carbamylcholine <br />
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[[3zdg]], [[3zdh]] - LsAChBP+ carbamylcholine analog<br />
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**[[3zdg]], [[3zdh]] - LsAChBP+ carbamylcholine analog<br />
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[[1uw6]] - LsAChBP+nicotine <br />
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**[[1uw6]] - LsAChBP+nicotine <br />
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[[4aft]] - AcAChBP+nicotine analog<br />
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**[[4aft]] - AcAChBP+nicotine analog<br />
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[[4bqt]] - AcAChBP+ cytisine<br />
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**[[4bqt]] - AcAChBP+ cytisine<br />
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[[2xz5]] – AcAChBP (mutant) + acetylcholine
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**[[2xz5]] – AcAChBP (mutant) + acetylcholine
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=== AChBP+others ===
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* AChBP+others
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[[2br7]] - AcAChBP+ HEPES<br />
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**[[2br7]] - AcAChBP+ HEPES<br />
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[[2y54]], [[2y56]], [[2y57]], [[2y58]] – AcAChBP residues 20-236 + azabicyclo-octan benzoate derivative
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**[[2y54]], [[2y56]], [[2y57]], [[2y58]] – AcAChBP residues 20-236 + azabicyclo-octan benzoate derivative
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===AChBP α-7===
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*AChBP α-7
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[[3sq6]], [[3sq9]] – AchBP h/Ls chimera
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**[[3sq6]], [[3sq9]] – AchBP h/Ls chimera
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}}
===Additional Resources===
===Additional Resources===

Revision as of 14:12, 11 November 2014

Template:STRUCTURE 2byn

Acetylcholine binding protein (AChBP) is secreted by snails into cholinergic synapses, where it modulates transmission by binding acetylcholine (ACh). Sequence alignment revealed high similarity to the extracellular domains of the ligand-binding subunits of the nicotinic acetylcholine receptor (nAChR). The crystal structure of the AChBP homopentamer indeed provides a valuable model for identifying the nature of the ligand-binding domains and of the subunit interfaces of the nAChR. Furthermore, crystal structures of complexes of AChBP with various agonists and antagonists have provided detailed insight into the neurotransmitter binding site of nAChRs. The images on the left and right correspond to one representative AChBP structure, i.e. the Acetylcholine binding protein from Aplysia californica (2byn).






</StructureSection>

3D Structures of Acetylcholine binding protein

Updated on 11-November-2014

Additional Resources

For additional information, see: Alzheimer's Disease

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, David Canner

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