This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1kn3
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1kn3.gif|left|200px]] | + | [[Image:1kn3.gif|left|200px]] |
| - | + | ||
| - | '''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)''' | + | {{Structure |
| + | |PDB= 1kn3 |SIZE=350|CAPTION= <scene name='initialview01'>1kn3</scene>, resolution 1.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= pebp-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1KN3 is a [ | + | 1KN3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:[http:// | + | The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12037323 12037323] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 20: | Line 29: | ||
[[Category: raf-1 kinase inhibitor]] | [[Category: raf-1 kinase inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:19:36 2008'' |
Revision as of 10:19, 20 March 2008
| |||||||
| , resolution 1.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | pebp-2 (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)
Overview
Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.
About this Structure
1KN3 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:12037323
Page seeded by OCA on Thu Mar 20 12:19:36 2008
