1kn3
From Proteopedia
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| - | [[Image:1kn3.gif|left|200px]] | + | [[Image:1kn3.gif|left|200px]] |
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| - | '''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)''' | + | {{Structure |
| + | |PDB= 1kn3 |SIZE=350|CAPTION= <scene name='initialview01'>1kn3</scene>, resolution 1.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= pebp-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KN3 is a [ | + | 1KN3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:[http:// | + | The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12037323 12037323] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: raf-1 kinase inhibitor]] | [[Category: raf-1 kinase inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:19:36 2008'' |
Revision as of 10:19, 20 March 2008
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| , resolution 1.80Å | |||||||
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| Gene: | pebp-2 (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)
Overview
Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.
About this Structure
1KN3 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:12037323
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