1kne
From Proteopedia
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| - | [[Image:1kne.gif|left|200px]] | + | [[Image:1kne.gif|left|200px]] |
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| - | '''Chromo domain of HP1 complexed with histone H3 tail containing trimethyllysine 9''' | + | {{Structure |
| + | |PDB= 1kne |SIZE=350|CAPTION= <scene name='initialview01'>1kne</scene>, resolution 2.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Chromo domain of HP1 complexed with histone H3 tail containing trimethyllysine 9''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KNE is a [ | + | 1KNE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNE OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail., Jacobs SA, Khorasanizadeh S, Science. 2002 Mar 15;295(5562):2080-3. Epub 2002 Feb 21. PMID:[http:// | + | Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail., Jacobs SA, Khorasanizadeh S, Science. 2002 Mar 15;295(5562):2080-3. Epub 2002 Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11859155 11859155] |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: trimethyllysine]] | [[Category: trimethyllysine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:19:44 2008'' |
Revision as of 10:19, 20 March 2008
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| , resolution 2.40Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Chromo domain of HP1 complexed with histone H3 tail containing trimethyllysine 9
Overview
The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines. Here, we present structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing. The histone tail inserts as a beta strand, completing the beta-sandwich architecture of the chromodomain. The methylammonium group is caged by three aromatic side chains, whereas adjacent residues form discerning contacts with one face of the chromodomain. Comparison of dimethyl- and trimethyllysine-containing complexes suggests a role for cation-pi and van der Waals interactions, with trimethylation slightly improving the binding affinity.
About this Structure
1KNE is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail., Jacobs SA, Khorasanizadeh S, Science. 2002 Mar 15;295(5562):2080-3. Epub 2002 Feb 21. PMID:11859155
Page seeded by OCA on Thu Mar 20 12:19:44 2008
