2v02
From Proteopedia
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Revision as of 15:36, 30 October 2007
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RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA
Overview
Calmodulin is a calcium sensor that is also capable of binding and being, activated by other metal ions. Of specific interest in this respect is, lead, which is known to be neurotoxic and to have a very high affinity, towards calmodulin. Crystal structures of human calmodulin complexed with, lead and barium ions have been solved. The results will help in, understanding the activation mechanisms of calmodulin by different heavy, metals and will provide a detailed view of a putative target for lead, neurotoxicity in humans.
About this Structure
2V02 is a [Single protein] structure of sequence from [Homo sapiens] with CA and BA as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
A structural insight into lead neurotoxicity and calmodulin activation by heavy metals., Kursula P, Majava V, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360
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