1kq8
From Proteopedia
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| - | [[Image:1kq8.jpg|left|200px]] | + | [[Image:1kq8.jpg|left|200px]] |
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| - | '''Solution Structure of Winged Helix Protein HFH-1''' | + | {{Structure |
| + | |PDB= 1kq8 |SIZE=350|CAPTION= <scene name='initialview01'>1kq8</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution Structure of Winged Helix Protein HFH-1''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KQ8 is a [ | + | 1KQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQ8 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence., Sheng W, Rance M, Liao X, Biochemistry. 2002 Mar 12;41(10):3286-93. PMID:[http:// | + | Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence., Sheng W, Rance M, Liao X, Biochemistry. 2002 Mar 12;41(10):3286-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11876636 11876636] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: winged helix protein]] | [[Category: winged helix protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:20:44 2008'' |
Revision as of 10:20, 20 March 2008
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Solution Structure of Winged Helix Protein HFH-1
Overview
The hepatocyte nuclear factor 3 (HNF-3)/fork head (fkh) family contains a large number of transcription factors that recognize divergent DNA sequences via a winged helix binding motif. HNF-3/fkh proteins show a broad profile of DNA sequence-specificity in which one DNA sequence can be recognized by more than one HNF-3/fkh protein and each individual HNF-3/fkh protein has several DNA binding sequences. In this study, heteronuclear NMR methods were used to study the structures of the DNA binding domain of a conserved winged helix protein HFH-1 and its DNA complexes. The structural comparison of winged helix proteins HFH-1 and Genesis and their DNA complexes indicates that even two highly conserved HNF-3 family members can adopt different local structures when they contact an identical DNA binding sequence, while one of these two HNF-3 proteins seems to adopt only slightly different structures on different DNA binding sites.
About this Structure
1KQ8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence., Sheng W, Rance M, Liao X, Biochemistry. 2002 Mar 12;41(10):3286-93. PMID:11876636
Page seeded by OCA on Thu Mar 20 12:20:44 2008
Categories: Rattus norvegicus | Single protein | Liao, X. | Rance, M. | Sheng, W. | Hfh-1 | Nmr | Structure | Winged helix protein
