1kqf

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[[Image:1kqf.gif|left|200px]]<br /><applet load="1kqf" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1kqf.gif|left|200px]]
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caption="1kqf, resolution 1.60&Aring;" />
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'''FORMATE DEHYDROGENASE N FROM E. COLI'''<br />
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{{Structure
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|PDB= 1kqf |SIZE=350|CAPTION= <scene name='initialview01'>1kqf</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=6MO:MOLYBDENUM(VI)+ION'>6MO</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Formate_dehydrogenase Formate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.2 1.2.1.2]
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|GENE=
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}}
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'''FORMATE DEHYDROGENASE N FROM E. COLI'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1KQF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=6MO:'>6MO</scene>, <scene name='pdbligand=SF4:'>SF4</scene>, <scene name='pdbligand=MGD:'>MGD</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=CDL:'>CDL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Formate_dehydrogenase Formate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.2 1.2.1.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQF OCA].
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1KQF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQF OCA].
==Reference==
==Reference==
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Molecular basis of proton motive force generation: structure of formate dehydrogenase-N., Jormakka M, Tornroth S, Byrne B, Iwata S, Science. 2002 Mar 8;295(5561):1863-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11884747 11884747]
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Molecular basis of proton motive force generation: structure of formate dehydrogenase-N., Jormakka M, Tornroth S, Byrne B, Iwata S, Science. 2002 Mar 8;295(5561):1863-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11884747 11884747]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Formate dehydrogenase]]
[[Category: Formate dehydrogenase]]
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[[Category: mpt]]
[[Category: mpt]]
[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
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[[Category: secys]]
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[[Category: secy]]
[[Category: selenium]]
[[Category: selenium]]
[[Category: selenocysteine]]
[[Category: selenocysteine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:36:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:20:51 2008''

Revision as of 10:20, 20 March 2008

Image:1kqf.gif


PDB ID 1kqf

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands: , , , and
Activity: Formate dehydrogenase, with EC number 1.2.1.2
Coordinates: save as pdb, mmCIF, xml



FORMATE DEHYDROGENASE N FROM E. COLI


Overview

The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a major component of Escherichia coli nitrate respiration, has been determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two heme b groups, and a menaquinone analog. These redox centers are aligned in a single chain, which extends almost 90 angstroms through the enzyme. The menaquinone reduction site associated with a possible proton pathway was also characterized. This structure provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes.

About this Structure

1KQF is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Molecular basis of proton motive force generation: structure of formate dehydrogenase-N., Jormakka M, Tornroth S, Byrne B, Iwata S, Science. 2002 Mar 8;295(5561):1863-8. PMID:11884747

Page seeded by OCA on Thu Mar 20 12:20:51 2008

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