1ktm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ktm.gif|left|200px]]<br /><applet load="1ktm" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1ktm.gif|left|200px]]
-
caption="1ktm" />
+
 
-
'''SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE'''<br />
+
{{Structure
 +
|PDB= 1ktm |SIZE=350|CAPTION= <scene name='initialview01'>1ktm</scene>
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
 +
|GENE=
 +
}}
 +
 
 +
'''SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1KTM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTM OCA].
+
1KTM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTM OCA].
==Reference==
==Reference==
-
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase., Liu G, Guibao CD, Zheng J, Mol Cell Biol. 2002 Apr;22(8):2751-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11909967 11909967]
+
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase., Liu G, Guibao CD, Zheng J, Mol Cell Biol. 2002 Apr;22(8):2751-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11909967 11909967]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 24: Line 33:
[[Category: nmr]]
[[Category: nmr]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:37:48 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:21:59 2008''

Revision as of 10:22, 20 March 2008

Image:1ktm.gif


PDB ID 1ktm

Drag the structure with the mouse to rotate
Activity: Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Coordinates: save as pdb, mmCIF, xml



SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE


Overview

Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeting (FAT) domain interacts with other focal adhesion molecules in integrin-mediated signaling. Localization of activated FAK to focal adhesions is indispensable for its function. Here we describe a solution structure of the FAT domain bound to a peptide derived from paxillin, a FAK-binding partner. The FAT domain is composed of four helices that form a "right-turn" elongated bundle; the globular fold is mainly maintained by hydrophobic interactions. The bound peptide further stabilizes the structure. Certain signaling events such as phosphorylation and molecule interplay may induce opening of the helix bundle. Such conformational change is proposed to precede departure of FAK from focal adhesions, which starts focal adhesion turnover.

About this Structure

1KTM is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase., Liu G, Guibao CD, Zheng J, Mol Cell Biol. 2002 Apr;22(8):2751-60. PMID:11909967

Page seeded by OCA on Thu Mar 20 12:21:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ktm"
Personal tools