1kxg

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[[Image:1kxg.gif|left|200px]]<br /><applet load="1kxg" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1kxg.gif|left|200px]]
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caption="1kxg, resolution 2.00&Aring;" />
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'''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''<br />
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{{Structure
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|PDB= 1kxg |SIZE=350|CAPTION= <scene name='initialview01'>1kxg</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene> and <scene name='pdbligand=DIO:1,4-DIETHYLENE DIOXIDE'>DIO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1KXG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CIT:'>CIT</scene> and <scene name='pdbligand=DIO:'>DIO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXG OCA].
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1KXG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXG OCA].
==Reference==
==Reference==
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Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11862220 11862220]
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Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11862220 11862220]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ztnf4]]
[[Category: ztnf4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:39:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:23:32 2008''

Revision as of 10:23, 20 March 2008

Image:1kxg.gif


PDB ID 1kxg

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.


Overview

B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 A resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity.

About this Structure

1KXG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:11862220

Page seeded by OCA on Thu Mar 20 12:23:32 2008

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