1l0s

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[[Image:1l0s.jpg|left|200px]]<br /><applet load="1l0s" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1l0s.jpg|left|200px]]
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caption="1l0s, resolution 2.30&Aring;" />
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'''Choristoneura fumiferana (spruce budworm) antifreeze protein isoform 337'''<br />
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{{Structure
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|PDB= 1l0s |SIZE=350|CAPTION= <scene name='initialview01'>1l0s</scene>, resolution 2.30&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CD:CADMIUM ION'>CD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Choristoneura fumiferana (spruce budworm) antifreeze protein isoform 337'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1L0S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Choristoneura_fumiferana Choristoneura fumiferana] with <scene name='pdbligand=CD:'>CD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0S OCA].
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1L0S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Choristoneura_fumiferana Choristoneura fumiferana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0S OCA].
==Reference==
==Reference==
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Crystal structure of beta-helical antifreeze protein points to a general ice binding model., Leinala EK, Davies PL, Jia Z, Structure. 2002 May;10(5):619-27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12015145 12015145]
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Crystal structure of beta-helical antifreeze protein points to a general ice binding model., Leinala EK, Davies PL, Jia Z, Structure. 2002 May;10(5):619-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12015145 12015145]
[[Category: Choristoneura fumiferana]]
[[Category: Choristoneura fumiferana]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: left-handed beta-helix]]
[[Category: left-handed beta-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:24:48 2008''

Revision as of 10:24, 20 March 2008

Image:1l0s.jpg


PDB ID 1l0s

Drag the structure with the mouse to rotate
, resolution 2.30Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Choristoneura fumiferana (spruce budworm) antifreeze protein isoform 337


Overview

Reported here is the 2.3 A resolution crystal structure of spruce budworm (Choristoneura fumiferana) antifreeze protein (CfAFP), solved by single anomalous scattering. The structure reveals an extremely regular left-handed beta-helical platform consisting of 15-amino acid loops with a repetitive Thr-X-Thr motif displayed on one of the helix's three faces. This motif results in a two-dimensional array of threonine residues in an identical orientation to those in the nonhomologous, right-handed beta-helical beetle AFP from Tenebrio molitor (TmAFP). The CfAFP structure led us to reevaluate our ice binding model, and the analysis of three possible modes of docking gives rise to a binding mechanism based on surface complementarity. This general mechanism is applicable to both fish and insect AFPs.

About this Structure

1L0S is a Single protein structure of sequence from Choristoneura fumiferana. Full crystallographic information is available from OCA.

Reference

Crystal structure of beta-helical antifreeze protein points to a general ice binding model., Leinala EK, Davies PL, Jia Z, Structure. 2002 May;10(5):619-27. PMID:12015145

Page seeded by OCA on Thu Mar 20 12:24:48 2008

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