1l1h

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[[Image:1l1h.gif|left|200px]]<br /><applet load="1l1h" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1l1h.gif|left|200px]]
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caption="1l1h, resolution 1.75&Aring;" />
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'''Crystal Structure of the Quadruplex DNA-Drug Complex'''<br />
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{{Structure
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|PDB= 1l1h |SIZE=350|CAPTION= <scene name='initialview01'>1l1h</scene>, resolution 1.75&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=PYN:3-PYRROLIDIN-1-YL-N-[6-(3-PYRROLIDIN-1-YL-PROPIONYLAMINO)-ACRIDIN-3-YL]-PROPIONAMIDE'>PYN</scene> and <scene name='pdbligand=K:POTASSIUM ION'>K</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal Structure of the Quadruplex DNA-Drug Complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1L1H is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=PYN:'>PYN</scene> and <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1H OCA].
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1L1H is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1H OCA].
==Reference==
==Reference==
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Structure of a G-quadruplex-ligand complex., Haider SM, Parkinson GN, Neidle S, J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12547195 12547195]
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Structure of a G-quadruplex-ligand complex., Haider SM, Parkinson GN, Neidle S, J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12547195 12547195]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Haider, S M.]]
[[Category: Haider, S M.]]
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[[Category: oxytricha]]
[[Category: oxytricha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:25:01 2008''

Revision as of 10:25, 20 March 2008

Image:1l1h.gif


PDB ID 1l1h

Drag the structure with the mouse to rotate
, resolution 1.75Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Quadruplex DNA-Drug Complex


Overview

Stabilisation of G-quadruplex structures formed from telomeric DNA, by means of quadruplex-selective ligands, is a means of inhibiting the telomerase enzyme from catalysing the synthesis of telomeric DNA repeats. In order to understand the molecular basis of ligand-quadruplex recognition, the crystal structure has been determined of such a complex, at 1.75A resolution. This complex is between a dimeric antiparallel G-quadruplex formed from the Oxytricha nova telomeric DNA sequence d(GGGGTTTTGGGG), and a di-substituted aminoalkylamido acridine compound. The structure shows that the acridine moiety is bound at one end of the stack of G-quartets, within one of the thymine loops. It is held in place by a combination of stacking interactions and specific hydrogen bonds with thymine bases. The stability of the ligand in this binding site has been confirmed by a 2ns molecular dynamics simulation.

About this Structure

1L1H is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structure of a G-quadruplex-ligand complex., Haider SM, Parkinson GN, Neidle S, J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:12547195

Page seeded by OCA on Thu Mar 20 12:25:01 2008

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