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1l1h
From Proteopedia
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| - | [[Image:1l1h.gif|left|200px]] | + | [[Image:1l1h.gif|left|200px]] |
| - | + | ||
| - | '''Crystal Structure of the Quadruplex DNA-Drug Complex''' | + | {{Structure |
| + | |PDB= 1l1h |SIZE=350|CAPTION= <scene name='initialview01'>1l1h</scene>, resolution 1.75Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PYN:3-PYRROLIDIN-1-YL-N-[6-(3-PYRROLIDIN-1-YL-PROPIONYLAMINO)-ACRIDIN-3-YL]-PROPIONAMIDE'>PYN</scene> and <scene name='pdbligand=K:POTASSIUM ION'>K</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of the Quadruplex DNA-Drug Complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1L1H is a [ | + | 1L1H is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1H OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a G-quadruplex-ligand complex., Haider SM, Parkinson GN, Neidle S, J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:[http:// | + | Structure of a G-quadruplex-ligand complex., Haider SM, Parkinson GN, Neidle S, J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12547195 12547195] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Haider, S M.]] | [[Category: Haider, S M.]] | ||
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[[Category: oxytricha]] | [[Category: oxytricha]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:25:01 2008'' |
Revision as of 10:25, 20 March 2008
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| , resolution 1.75Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Quadruplex DNA-Drug Complex
Overview
Stabilisation of G-quadruplex structures formed from telomeric DNA, by means of quadruplex-selective ligands, is a means of inhibiting the telomerase enzyme from catalysing the synthesis of telomeric DNA repeats. In order to understand the molecular basis of ligand-quadruplex recognition, the crystal structure has been determined of such a complex, at 1.75A resolution. This complex is between a dimeric antiparallel G-quadruplex formed from the Oxytricha nova telomeric DNA sequence d(GGGGTTTTGGGG), and a di-substituted aminoalkylamido acridine compound. The structure shows that the acridine moiety is bound at one end of the stack of G-quartets, within one of the thymine loops. It is held in place by a combination of stacking interactions and specific hydrogen bonds with thymine bases. The stability of the ligand in this binding site has been confirmed by a 2ns molecular dynamics simulation.
About this Structure
1L1H is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of a G-quadruplex-ligand complex., Haider SM, Parkinson GN, Neidle S, J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:12547195
Page seeded by OCA on Thu Mar 20 12:25:01 2008
Categories: Protein complex | Haider, S M. | Neidle, S. | Parkinson, G N. | K | PYN | Four-stranded dna | G-quadruplex | Oxytricha
