2wll

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[[Image:2wll.png|left|200px]]
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==POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI==
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<StructureSection load='2wll' size='340' side='right' caption='[[2wll]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p7b|1p7b]], [[1xl4|1xl4]], [[2wln|2wln]], [[2wlo|2wlo]], [[2wli|2wli]], [[2wlm|2wlm]], [[1xl6|1xl6]], [[2wlh|2wlh]], [[2wlk|2wlk]], [[2wlj|2wlj]], [[2x6b|2x6b]], [[2x6a|2x6a]], [[2x6c|2x6c]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHROMOSOME 1 KIRBAC1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [http://www.ebi.ac.uk/pdbsum/2wll PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wll_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.
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{{STRUCTURE_2wll| PDB=2wll | SCENE= }}
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Crystal structure of the potassium channel KirBac1.1 in the closed state.,Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8. PMID:12738871<ref>PMID:12738871</ref>
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===POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12738871}}
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==About this Structure==
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[[2wll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA].
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==See Also==
==See Also==
*[[Potassium Channel|Potassium Channel]]
*[[Potassium Channel|Potassium Channel]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012738871</ref><ref group="xtra">PMID:020564790</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
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[[Category: Caputo, A T.]]
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[[Category: Caputo, A T]]
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[[Category: Clarke, O B.]]
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[[Category: Clarke, O B]]
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[[Category: Gulbis, J M.]]
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[[Category: Gulbis, J M]]
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[[Category: Hill, A P.]]
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[[Category: Hill, A P]]
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[[Category: Smith, B J.]]
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[[Category: Smith, B J]]
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[[Category: Vandenberg, J I.]]
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[[Category: Vandenberg, J I]]
[[Category: Cytosolic assembly]]
[[Category: Cytosolic assembly]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]

Revision as of 08:18, 12 November 2014

POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI

2wll, resolution 3.65Å

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