1l2q

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[[Image:1l2q.jpg|left|200px]]<br /><applet load="1l2q" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1l2q.jpg|left|200px]]
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caption="1l2q, resolution 1.70&Aring;" />
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'''Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)'''<br />
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{{Structure
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|PDB= 1l2q |SIZE=350|CAPTION= <scene name='initialview01'>1l2q</scene>, resolution 1.70&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=X7O:5-AMINO-3-METHYL-PYRROLIDINE-2-CARBOXYLIC+ACID'>X7O</scene> and <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC ACID'>BGX</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1L2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri] with <scene name='pdbligand=NH4:'>NH4</scene>, <scene name='pdbligand=X7O:'>X7O</scene> and <scene name='pdbligand=BGX:'>BGX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA].
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1L2Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA].
==Reference==
==Reference==
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A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12029132 12029132]
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A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12029132 12029132]
[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tim barrel]]
[[Category: tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:25:35 2008''

Revision as of 10:25, 20 March 2008

Image:1l2q.jpg


PDB ID 1l2q

Drag the structure with the mouse to rotate
, resolution 1.70Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)


Overview

Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.

About this Structure

1L2Q is a Single protein structure of sequence from Methanosarcina barkeri. Full crystallographic information is available from OCA.

Reference

A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:12029132

Page seeded by OCA on Thu Mar 20 12:25:35 2008

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