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Actin

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{{STRUCTURE_3hbt| PDB=3hbt | SIZE=400| SCENE=Actin/Cv/1 |right|CAPTION=Native G-actin with methyl-histidine complex with ATP, sulfate and Ca+2 ion (green) [[3hbt]] }}
{{STRUCTURE_3hbt| PDB=3hbt | SIZE=400| SCENE=Actin/Cv/1 |right|CAPTION=Native G-actin with methyl-histidine complex with ATP, sulfate and Ca+2 ion (green) [[3hbt]] }}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== α actin 1 (Aa) ===
+
* α actin 1 (Aa)
-
 
+
-
[[2w49]] – cAa +troponin C+ troponin T+ troponin I+ tropomyosin α-1 – chicken<br />
+
-
[[1mdu]] – cAa+hGelsolin<br />
+
-
[[3hbt]], [[2zwh]], [[1nwk]], [[1j6z]], [[3g37]], [[2y83]] – rAa – rabbit<br />
+
-
[[4a7f]], [[4a7h]], [[4a7l]] – rAa + tropomyosin α-1 + myosin heavy chain (mutant) – Cryo EM<br />
+
-
[[2q1n]], [[2q31]], [[2a5x]], [[1rdw]], [[1rfq]], [[1lcu]] – rAa – dimer<br />
+
-
[[3mfp]], [[4a7n]] – rAa – Cryo EM<br />
+
-
[[2q36]], [[1qz5]] – rAa+kabiramide C – dimer<br />
+
-
[[2hmp]] – rAa – protease cleaved<br />
+
-
[[2zwh]], [[2gwj]], [[2gwk]] – rAa-ATP<br />
+
-
[[2vyp]] – rAa+myxobacterial rhizopodin<br />
+
-
[[2v51]], [[2v52]], [[2yje]], [[2yjf]] – rAa+mMKL/Myocardin-like protein – mouse (m)<br />
+
-
[[2vcp]] – rAa+ neural wiskott-aldrich syndrome protein (hWASP) – human (h)<br />
+
-
[[2a3z]], [[2a40]], [[2a41]] – rAa+cDNase I+domains of hWASP – cow (c)<br />
+
-
[[2ff3]] - rAa+ hGelsolin +domains of hWASP <br />
+
-
[[2a42]] – rAa+cDNase I<br />
+
-
[[4eah]] – rAa + formin-like protein 3 FH2 domain<br />
+
-
[[3daw]] – rAa+mTwinfilin-1<br />
+
-
[[3buz]] – rAa+Iota toxin component IA<br />
+
-
[[3b5u]] – rAa filament – fiber diffraction<br />
+
-
[[1eqy]], [[3cjb]], [[1p8z]], [[3ffk]] – rAa+hGelsolin<br />
+
-
[[1rgi]] - rAa+hoGelsolin – horse (ho)<br />
+
-
[[1t44]] - rAa+hGelsolin:mThymosin β-4 <br />
+
-
[[3u8x]] - rAa+DmThymosin β-4 - ''Drosophila melanogaster''<br />
+
-
[[1esv]] - rAa+hGelsolin+ latrunculin A<br />
+
-
[[3cjc]] - rAa+hGelsolin+cDNase I<br />
+
-
[[2d1k]] - rAa+hWH2 domain of MIN+cDNase I<br />
+
-
[[2pbd]] – rAa+hProfilin-1<br />
+
-
[[2pav]] - rAa+hProfilin-1+hVASP<br />
+
-
[[2q97]] – rAa+toxofilin – ''Toxoplasma gondii''<br />
+
-
[[2q0r]] – rAa+pectenotoxin-2<br />
+
-
[[2q0u]] - rAa+pectenotoxin-2+latrunculin B<br />
+
-
[[1ijj]] - rAa+latrunculin A<br />
+
-
[[2fxu]] – rAa+bistramide A<br />
+
-
[[1wua]] – rAa+alpyronine A<br />
+
-
[[2asm]], [[2asp]] – rAa+reidispongiolide<br />
+
-
[[2aso]] – rAa+sphinxolide B<br />
+
-
[[1yxq]] – rAa+swinholide A<br />
+
-
[[1y64]] – rAa+yBNI1 domain FH2 - yeast<br />
+
-
[[1sqk]] – rAa+DmCiboulot <br />
+
-
[[3sjh]], [[3u9d]], [[3u9z]] - rAa+DmCiboulot thymosin β-4 domain<br />
+
-
[[3mn5]] – rAa+ DmSpire WH2 domain<br />
+
-
[[2ff6]] - rAa+DmCiboulot+hGelsolin <br />
+
-
[[1s22]] – rAa+ulapualide A<br />
+
-
[[1qz6]] – rAa+jaspisamide A<br />
+
-
[[1lot]], [[1kxp]], [[1ma9]] – rAa+hVitamin D binding protein<br />
+
-
[[3m1f]] – rAa+VOPL WH2 domain<br />
+
-
[[3m3n]] – rAa+mN-WASP<br />
+
-
[[3m6g]] – rAa+lobophorolide<br />
+
-
[[3tpq]] – rAa + MAL RPEL domain<br />
+
-
[[3ue5]] – rAa + spire domain D<br />
+
-
[[4gy2]] – rAa + ι toxin component IA <br />
+
-
[[4h0t]] – rAa + ι toxin component IA + ADPR<br />
+
-
[[4h03]], [[4h0v]], [[4h0x]], [[4h0y]] – rAa + ι toxin component IA + NAD<br />
+
-
[[4jhd]] – DmAa + protein cordon-bleu WH2 domain<br />
+
-
=== β actin (Ab) ===
+
**[[2w49]] – cAa +troponin C+ troponin T+ troponin I+ tropomyosin α-1 – chicken<br />
 +
**[[1mdu]] – cAa+hGelsolin<br />
 +
**[[3hbt]], [[2zwh]], [[1nwk]], [[1j6z]], [[3g37]], [[2y83]] – rAa – rabbit<br />
 +
**[[4a7f]], [[4a7h]], [[4a7l]] – rAa + tropomyosin α-1 + myosin heavy chain (mutant) – Cryo EM<br />
 +
**[[2q1n]], [[2q31]], [[2a5x]], [[1rdw]], [[1rfq]], [[1lcu]] – rAa – dimer<br />
 +
**[[3mfp]], [[4a7n]] – rAa – Cryo EM<br />
 +
**[[2q36]], [[1qz5]] – rAa+kabiramide C – dimer<br />
 +
**[[2hmp]] – rAa – protease cleaved<br />
 +
**[[2zwh]], [[2gwj]], [[2gwk]] – rAa-ATP<br />
 +
**[[2vyp]] – rAa+myxobacterial rhizopodin<br />
 +
**[[2v51]], [[2v52]], [[2yje]], [[2yjf]] – rAa+mMKL/Myocardin-like protein – mouse (m)<br />
 +
**[[2vcp]] – rAa+ neural wiskott-aldrich syndrome protein (hWASP) – human (h)<br />
 +
**[[2a3z]], [[2a40]], [[2a41]] – rAa+cDNase I+domains of hWASP – cow (c)<br />
 +
**[[2ff3]] - rAa+ hGelsolin +domains of hWASP <br />
 +
**[[2a42]] – rAa+cDNase I<br />
 +
**[[4eah]] – rAa + formin-like protein 3 FH2 domain<br />
 +
**[[3daw]] – rAa+mTwinfilin-1<br />
 +
**[[3buz]] – rAa+Iota toxin component IA<br />
 +
**[[3b5u]] – rAa filament – fiber diffraction<br />
 +
**[[1eqy]], [[3cjb]], [[1p8z]], [[3ffk]] – rAa+hGelsolin<br />
 +
**[[1rgi]] - rAa+hoGelsolin – horse (ho)<br />
 +
**[[1t44]] - rAa+hGelsolin:mThymosin β-4 <br />
 +
**[[3u8x]] - rAa+DmThymosin β-4 - ''Drosophila melanogaster''<br />
 +
**[[1esv]] - rAa+hGelsolin+ latrunculin A<br />
 +
**[[3cjc]] - rAa+hGelsolin+cDNase I<br />
 +
**[[2d1k]] - rAa+hWH2 domain of MIN+cDNase I<br />
 +
**[[2pbd]] – rAa+hProfilin-1<br />
 +
**[[2pav]] - rAa+hProfilin-1+hVASP<br />
 +
**[[2q97]] – rAa+toxofilin – ''Toxoplasma gondii''<br />
 +
**[[2q0r]] – rAa+pectenotoxin-2<br />
 +
**[[2q0u]] - rAa+pectenotoxin-2+latrunculin B<br />
 +
**[[1ijj]] - rAa+latrunculin A<br />
 +
**[[2fxu]] – rAa+bistramide A<br />
 +
**[[1wua]] – rAa+alpyronine A<br />
 +
**[[2asm]], [[2asp]] – rAa+reidispongiolide<br />
 +
**[[2aso]] – rAa+sphinxolide B<br />
 +
**[[1yxq]] – rAa+swinholide A<br />
 +
**[[1y64]] – rAa+yBNI1 domain FH2 - yeast<br />
 +
**[[1sqk]] – rAa+DmCiboulot <br />
 +
**[[3sjh]], [[3u9d]], [[3u9z]] - rAa+DmCiboulot thymosin β-4 domain<br />
 +
**[[3mn5]] – rAa+ DmSpire WH2 domain<br />
 +
**[[2ff6]] - rAa+DmCiboulot+hGelsolin <br />
 +
**[[1s22]] – rAa+ulapualide A<br />
 +
**[[1qz6]] – rAa+jaspisamide A<br />
 +
**[[1lot]], [[1kxp]], [[1ma9]] – rAa+hVitamin D binding protein<br />
 +
**[[3m1f]] – rAa+VOPL WH2 domain<br />
 +
**[[3m3n]] – rAa+mN-WASP<br />
 +
**[[3m6g]] – rAa+lobophorolide<br />
 +
**[[3tpq]] – rAa + MAL RPEL domain<br />
 +
**[[3ue5]] – rAa + spire domain D<br />
 +
**[[4gy2]] – rAa + ι toxin component IA <br />
 +
**[[4h0t]] – rAa + ι toxin component IA + ADPR<br />
 +
**[[4h03]], [[4h0v]], [[4h0x]], [[4h0y]] – rAa + ι toxin component IA + NAD<br />
 +
**[[4jhd]] – DmAa + protein cordon-bleu WH2 domain<br />
-
[[3lue]] – hAb+hAlpha-actinin <br />
+
* β actin (Ab)
-
[[3byh]] – hAb+hFimbrin ABD2 – Cryo EM<br />
+
-
[[2oan]] – cAb<br />
+
-
[[3j0s]] – cAb + cofilin 2<br />
+
-
[[3u4l]], [[3ub5]] – Ab + profilin-1 - bovine
+
-
=== γ 1 actin (Ag) ===
+
**[[3lue]] – hAb+hAlpha-actinin <br />
 +
**[[3byh]] – hAb+hFimbrin ABD2 – Cryo EM<br />
 +
**[[2oan]] – cAb<br />
 +
**[[3j0s]] – cAb + cofilin 2<br />
 +
**[[3u4l]], [[3ub5]] – Ab + profilin-1 - bovine
-
[[1atn]] – rAg+cDNase I<br />
+
* γ 1 actin (Ag)
-
[[3chw]] – Major DdAg+hProfilin+poly-Pro repeat – ''Dictyostelium discoideum''<br />
+
-
[[3ci5]], [[3cip]], [[1nmd]] - Major DdAg+hGelsolin<br />
+
-
[[3a5l]], [[3a5m]], [[3a5n]], [[3a5o]] - Major DdAg+hGelsolin (mutant)<br />
+
-
[[1c0g]], [[1dej]] – DdAg:tetrahymenatA+hGelsolin<br />
+
-
[[1nm1]] - DdAg+hGelsolin+Mg-ATP<br />
+
-
[[1nlv]], [[1c0f]] – DdAg+hGelsolin<br />
+
-
[[1d4x]] – Ag 1/3+hGelsolin – ''C. elegans''<br />
+
-
[[1h1v]] – hAg+rGelsolin<br />
+
-
[[1hlu]], [[2btf]] – cA+cProfilin<br />
+
-
[[1o1g]], [[1o1a]], [[1o1b]], [[1o1c]], [[1o1d]], [[1o1e]], [[1o1f]], [[1o18]], [[1o19]], [[1mvw]], [[1m8q]] –cAg+cMyosin II - tomography<br />
+
-
[[3eks]] – DmAg 5c (mutant)<br />
+
-
[[3eku]] – DmAg 5c (mutant)+cytochalasin D<br />
+
-
[[3el2]], [[2hf4]] - DmAg 5c (mutant)+Ca-ATP<br />
+
-
[[2hf3]] - DmAg 5c (mutant)+Ca-ADP<br />
+
-
[[3w3d]] – cAg + DNase I<br />
+
-
[[3b63]] – actin filament – ''Limulus polyphemus''<br />
+
-
[[1yvn]] – yA (mutant)+hGelsolin <br />
+
-
[[1yag]] - yA+hGelsolin<br />
+
-
[[3mmv]] – DmA-5C+spire WH2 domain<br />
+
-
[[3mn6]], [[3mn7]], [[3mn9]] - DmA-5C (mutant)+spire<br />
+
-
[[4efh]] – A + spire domains C,D – ''Acanthamoeba castellanii''
+
 +
**[[1atn]] – rAg+cDNase I<br />
 +
**[[3chw]] – Major DdAg+hProfilin+poly-Pro repeat – ''Dictyostelium discoideum''<br />
 +
**[[3ci5]], [[3cip]], [[1nmd]] - Major DdAg+hGelsolin<br />
 +
**[[3a5l]], [[3a5m]], [[3a5n]], [[3a5o]] - Major DdAg+hGelsolin (mutant)<br />
 +
**[[1c0g]], [[1dej]] – DdAg:tetrahymenatA+hGelsolin<br />
 +
**[[1nm1]] - DdAg+hGelsolin+Mg-ATP<br />
 +
**[[1nlv]], [[1c0f]] – DdAg+hGelsolin<br />
 +
**[[1d4x]] – Ag 1/3+hGelsolin – ''C. elegans''<br />
 +
**[[1h1v]] – hAg+rGelsolin<br />
 +
**[[1hlu]], [[2btf]] – cAg+cProfilin<br />
 +
**[[1o1g]], [[1o1a]], [[1o1b]], [[1o1c]], [[1o1d]], [[1o1e]], [[1o1f]], [[1o18]], [[1o19]], [[1mvw]], [[1m8q]] –cAg+cMyosin II - tomography<br />
 +
**[[3eks]] – DmAg 5c (mutant)<br />
 +
**[[3eku]] – DmAg 5c (mutant)+cytochalasin D<br />
 +
**[[3el2]], [[2hf4]] - DmAg 5c (mutant)+Ca-ATP<br />
 +
**[[2hf3]] - DmAg 5c (mutant)+Ca-ADP<br />
 +
**[[3w3d]] – cAg + DNase I<br />
 +
**[[3b63]] – actin filament – ''Limulus polyphemus''<br />
 +
**[[1yvn]] – yA (mutant)+hGelsolin <br />
 +
**[[1yag]] - yA+hGelsolin<br />
 +
**[[3mmv]] – DmA-5C+spire WH2 domain<br />
 +
**[[3mn6]], [[3mn7]], [[3mn9]] - DmA-5C (mutant)+spire<br />
 +
**[[4efh]] – A + spire domains C,D – ''Acanthamoeba castellanii''
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:36, 12 November 2014

Template:STRUCTURE 3hbt

Actin is a protein found in all eukaryotic cells. It is the monomer of two types of filaments: microfilaments which are part of the cytoskeleton and thin filaments which are part of muscles. Three isoforms of actin are identified: α (Aa) (or G-actin) found in muscle tissue, β (Ab) and γ (Ag) actins are components of the cytoskeleton. F-actin is Aa bound to ATP. The images at the left and at the right correspond to one representative Actin, i.e. the crystal structure of rabbit Native G-actin (3hbt). For more details see:
*F-actin
*Non-polymerizable monomeric actin.
(PDB entries 1hlu and 2btf; morph was taken from Gallery of Morphs of the Yale Morph Server).






3D Structures of Actin

Updated on 12-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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