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Aldehyde dehydrogenase
From Proteopedia
(Difference between revisions)
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *ALDH class 1 | |
| - | [[3fx4]] – ALDH1 + NADP + inhibitor – pig<BR /> | + | **[[3fx4]] – ALDH1 + NADP + inhibitor – pig<BR /> |
| - | [[1bxs]] – ALDH1 - sheep<br /> | + | **[[1bxs]] – ALDH1 - sheep<br /> |
| - | [[1o9j]] – ALDH1 + NAD – Elephant shrew<br /> | + | **[[1o9j]] – ALDH1 + NAD – Elephant shrew<br /> |
| - | [[3rhj]], [[3rhl]], [[3rho]], [[3rhp]], [[3rhq]], [[3rhr]] – rALDH1 C- terminal (mutant) + NADP – rat<br /> | + | **[[3rhj]], [[3rhl]], [[3rho]], [[3rhp]], [[3rhq]], [[3rhr]] – rALDH1 C- terminal (mutant) + NADP – rat<br /> |
| - | [[3rhm]] - rALDH1 C- terminal<br /> | + | **[[3rhm]] - rALDH1 C- terminal<br /> |
| - | [[1hso]] – hALDH1 α subunit + Zn + NAD<br /> | + | **[[1hso]] – hALDH1 α subunit + Zn + NAD<br /> |
| - | [[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD | + | **[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD |
| - | + | *ALDH class 2 | |
| - | [[3n80]], [[1o05]] – hALDH2 residues 18-517- human<BR /> | + | **[[3n80]], [[1o05]] – hALDH2 residues 18-517- human<BR /> |
| - | [[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR /> | + | **[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR /> |
| - | [[1ag8]] – bALDH NAD binding domain - bovine | + | **[[1ag8]] – bALDH NAD binding domain - bovine |
| - | + | *ALDH2 binary complex | |
| - | [[3inj]], [[3inl]] - hALDH2 residues 18-517 + agonist<BR /> | + | **[[3inj]], [[3inl]] - hALDH2 residues 18-517 + agonist<BR /> |
| - | [[2vle]] - hALDH2 residues 24-517 + daidzin<BR /> | + | **[[2vle]] - hALDH2 residues 24-517 + daidzin<BR /> |
| - | [[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]] - hALDH2 residues 18-517 + NAD<BR /> | + | **[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]] - hALDH2 residues 18-517 + NAD<BR /> |
| - | [[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR /> | + | **[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR /> |
| - | [[3sz9]] - hALDH2 residues 18-517 + inhibitor<br /> | + | **[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br /> |
| - | [[1a4z]] – bALDH2 NAD-binding domain + NAD<BR /> | + | **[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR /> |
| - | + | *ALDH2 ternary complex | |
| - | [[1o01]] - hALDH2 residues 18-517 + NADH + aldehyde<br /> | + | **[[1o01]] - hALDH2 residues 18-517 + NADH + aldehyde<br /> |
| - | [[4fqf]] - hALDH2 residues 18-517 + NAD + NO2<br /> | + | **[[4fqf]] - hALDH2 residues 18-517 + NAD + NO2<br /> |
| - | [[4fr8]] - hALDH2 residues 18-517 (mutant) + NAD + ADP + nitroglycerin | + | **[[4fr8]] - hALDH2 residues 18-517 (mutant) + NAD + ADP + nitroglycerin |
| - | + | *ALDH class 3 | |
| - | [[1ad3]] – rALDH3<br /> | + | **[[1ad3]] – rALDH3<br /> |
| - | [[3sza]] - hALDH3A1<br /> | + | **[[3sza]] - hALDH3A1<br /> |
| - | [[3szb]] – hALDH3A1 + inhibitor<br /> | + | **[[3szb]] – hALDH3A1 + inhibitor<br /> |
| - | [[4h80]] - hALDH3A1 (mutant) + inhibitor<br /> | + | **[[4h80]] - hALDH3A1 (mutant) + inhibitor<br /> |
| - | [[4qgk]] – hALDH3A2 + ligand<br /> | + | **[[4qgk]] – hALDH3A2 + ligand<br /> |
| - | + | *NAD-dependent ALDH | |
| - | [[2w8n]], [[2w8o]], [[2w8r]] – Succinate–semi-hALDH family 5<BR /> | + | ***[[2w8n]], [[2w8o]], [[2w8r]] – Succinate–semi-hALDH family 5<BR /> |
| - | [[2w8p]] - Succinate–semi-hALDH family 5 (mutant) <BR /> | + | ***[[2w8p]] - Succinate–semi-hALDH family 5 (mutant) <BR /> |
| - | [[3r31]] – Betaine-ALDH – ''Agrobacterium tumefaciens''<BR /> | + | ***[[3r31]] – Betaine-ALDH – ''Agrobacterium tumefaciens''<BR /> |
| - | [[3ed6]], [[4mpb]], [[4nu9]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR /> | + | ***[[3ed6]], [[4mpb]], [[4nu9]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR /> |
| - | [[1a4s]] - Betaine-cALDH - cod<BR /> | + | ***[[1a4s]] - Betaine-cALDH - cod<BR /> |
| - | [[3llg]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR /> | + | ***[[3llg]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR /> |
| - | [[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR /> | + | ***[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR /> |
| - | [[2nac]] – Formate-PsALDH<BR /> | + | ***[[2nac]] – Formate-PsALDH<BR /> |
| - | [[3i44]] – ALDH – ''Bartonella henselae''<BR /> | + | ***[[3i44]] – ALDH – ''Bartonella henselae''<BR /> |
| - | [[3ek1]] – ALDH – ''Brucella melitensis''<br /> | + | ***[[3ek1]] – ALDH – ''Brucella melitensis''<br /> |
| - | [[3ros]] – ALDH – ''Lactobacillus acidophilus''<br /> | + | ***[[3ros]] – ALDH – ''Lactobacillus acidophilus''<br /> |
| - | [[3r64]] – ALDH – ''Corynebacterium glutamicum''<br /> | + | ***[[3r64]] – ALDH – ''Corynebacterium glutamicum''<br /> |
| - | [[3rhe]] – Benzaldehyde-ALDH – ''Legionella pneumophila''<br /> | + | ***[[3rhe]] – Benzaldehyde-ALDH – ''Legionella pneumophila''<br /> |
| - | [[3u4j]], [[4i3t]] – SmALDH – ''Sinorhizobium meliloti'' | + | ***[[3u4j]], [[4i3t]] – SmALDH – ''Sinorhizobium meliloti'' |
| - | + | **Binary complexes | |
| - | [[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> | + | ***[[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> |
| - | [[3fg0]], [[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<BR /> | + | ***[[3fg0]], [[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<BR /> |
| - | [[4ni4]] - Betaine-SaALDH (mutant) + NAD<br /> | + | ***[[4ni4]] - Betaine-SaALDH (mutant) + NAD<br /> |
| - | [[1bpw]] - Betaine-cALDH + NAD<BR /> | + | ***[[1bpw]] - Betaine-cALDH + NAD<BR /> |
| - | [[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> | + | ***[[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> |
| - | [[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> | + | ***[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> |
| - | [[2nad]] - Formate-PsALDH + NAD – ''Pseudomonas''<BR /> | + | ***[[2nad]] - Formate-PsALDH + NAD – ''Pseudomonas''<BR /> |
| - | [[1bi9]] – Retinal-rALDH2 + NAD<BR /> | + | ***[[1bi9]] – Retinal-rALDH2 + NAD<BR /> |
| - | [[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br /> | + | ***[[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br /> |
| - | [[4a0m]] – spALDH + NAD – spinach<br /> | + | ***[[4a0m]] – spALDH + NAD – spinach<br /> |
| - | [[3iwk]] – amino-ALDH + NAD – pea<br /> | + | ***[[3iwk]] – amino-ALDH + NAD – pea<br /> |
| - | [[3ju8]] - Succinylglutamic–semi-PaALDH + NAD – ''Pseudomonas aeruginosa''<br /> | + | ***[[3ju8]] - Succinylglutamic–semi-PaALDH + NAD – ''Pseudomonas aeruginosa''<br /> |
| - | [[4c3s]] - ALDH + NAD – ''Clostridium phytofermentans''<br /> | + | ***[[4c3s]] - ALDH + NAD – ''Clostridium phytofermentans''<br /> |
| - | [[4i3u]] – SmALDH + phosphonoacetaldehyde<br /> | + | ***[[4i3u]] – SmALDH + phosphonoacetaldehyde<br /> |
| - | + | **Ternary complexes | |
| - | [[2gsd]] – Formate-ALDH + NAD + azide – ''Moraxella''<BR /> | + | ***[[2gsd]] – Formate-ALDH + NAD + azide – ''Moraxella''<BR /> |
| - | [[1nvm]] – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD<BR /> | + | ***[[1nvm]] – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD<BR /> |
| - | [[1llu]] - PaALDH + NAD + alcohol<br /> | + | ***[[1llu]] - PaALDH + NAD + alcohol<br /> |
| - | [[4i3v]], [[4i3w]] – SmALDH + aldehyde derivative + NAD<br /> | + | ***[[4i3v]], [[4i3w]] – SmALDH + aldehyde derivative + NAD<br /> |
| - | [[4i3x]] – SmALDH + phosphonoacete + NAD<br /> | + | ***[[4i3x]] – SmALDH + phosphonoacete + NAD<br /> |
| - | + | *NADP-dependent ALDH | |
| - | [[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<BR /> | + | ***[[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<BR /> |
| - | [[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR /> | + | ***[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR /> |
| - | [[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br /> | + | ***[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br /> |
| - | [[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br /> | + | ***[[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br /> |
| - | [[3ifg]], [[3ifh]] - Succinate–semi-ALDH – ''Burkholderia pseudomallei''<br /> | + | ***[[3ifg]], [[3ifh]] - Succinate–semi-ALDH – ''Burkholderia pseudomallei''<br /> |
| - | [[3rh9]] - Succinate–semi-ALDH – ''Marinobacter aquaeolei''<br /> | + | ***[[3rh9]] - Succinate–semi-ALDH – ''Marinobacter aquaeolei''<br /> |
| - | [[3uw3]] - aspartate–semi-ALDH – ''Burkholderia thailandensis''<br /> | + | ***[[3uw3]] - aspartate–semi-ALDH – ''Burkholderia thailandensis''<br /> |
| - | [[3v4c]] - SmALDH | + | ***[[3v4c]] - SmALDH |
| - | + | **Binary complexes | |
| - | [[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - Betaine-PaALDH + NADP<BR /> | + | ***[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - Betaine-PaALDH + NADP<BR /> |
| - | [[3lv1]] – Benzaldehyde-PpALDH3 + NADP – ''Pseudomonas putida''<BR /> | + | ***[[3lv1]] – Benzaldehyde-PpALDH3 + NADP – ''Pseudomonas putida''<BR /> |
| - | [[2ilu]] - Lactaldehyde-EcALDH + NADP<BR /> | + | ***[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR /> |
| - | [[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br /> | + | ***[[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br /> |
| - | [[2o2q]], [[2o2r]] - Formyltetrahydrofolate-rALDH C-terminal + NADP<BR /> | + | ***[[2o2q]], [[2o2r]] - Formyltetrahydrofolate-rALDH C-terminal + NADP<BR /> |
| - | [[3b4w]] - MtALDH + NADP – ''Mycobacterium tuberculosis''<BR /> | + | ***[[3b4w]] - MtALDH + NADP – ''Mycobacterium tuberculosis''<BR /> |
| - | [[1eyy]], [[1ez0]] – ALDH + NADP – ''Vibrio harveyi''<br /> | + | ***[[1eyy]], [[1ez0]] – ALDH + NADP – ''Vibrio harveyi''<br /> |
| - | [[3jz4]] - Succinate–semi-EcALDH + NADP<br /> | + | ***[[3jz4]] - Succinate–semi-EcALDH + NADP<br /> |
| - | [[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br /> | + | ***[[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br /> |
| - | [[4h73]] - ALDH + NADP – ''Pyrobaculum''<br /> | + | ***[[4h73]] - ALDH + NADP – ''Pyrobaculum''<br /> |
| - | + | **Ternary complexes | |
| - | [[3lns]] - Benzaldehyde-PpALDH3 + NADP + benzoate<BR /> | + | ***[[3lns]] - Benzaldehyde-PpALDH3 + NADP + benzoate<BR /> |
| - | [[2imp]] - Lactaldehyde-EcALDH + NADH + lactate<BR /> | + | ***[[2imp]] - Lactaldehyde-EcALDH + NADH + lactate<BR /> |
| - | [[2vro]] – BxALDH + NADP + alcohol | + | ***[[2vro]] – BxALDH + NADP + alcohol |
| - | [[3k9d]] – ALDH – ''Listeria monocytogenes'' | + | ***[[3k9d]] – ALDH – ''Listeria monocytogenes'' |
| - | + | *Antiquitin | |
| - | [[2jg7]] – Antiquitin – Acanthopagrus schlegeli | + | **[[2jg7]] – Antiquitin – ''Acanthopagrus schlegeli'' |
| - | + | ||
| - | + | ||
| + | **[[3my7]] – ALDH – ''Vibrio parahaemolyticus'' | ||
| + | }} | ||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:13, 16 November 2014
Image:1nzx.png
Crystal Structure of Aldehyde dehydrogenase, 1nzx
Aldehyde dehydrogenase (ALDH) converts aldehydes to carboxylic acids while reducing NAD+ to NADH. In mammals there are 3 classes of ALDH and each contain constitutive and inducible forms.
- ALDH class 1 is cytosolic.
- ALDH class 2 is mitochondrial.
- ALDH class 3 is found in tumors, stomach and cornea. ALDH3A1 is soluble and has substrate specificity to bulky aromatic aldehydes. ALDH3A2 is a fatty ALDH (FALDH). FALDH was found to have an additional gatekeeper helix at the substrate funnel entrance that is shaping the enzymes substrate specificity. [1]
- ALDH family 7 member A1 is known as antiquitin and functions in the detoxification of aldehydes.
3D Structures of Aldehyde dehydrogenase
Updated on 16-November-2014
References
- ↑ Keller, Markus A.; Zander, Ulrich; Fuchs, Julian E.; Kreutz, Christoph; Watschinger, Katrin et al. (2014). A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature Communications vol. 5.
