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Antithrombin

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1att]] – AT-III – bovine
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*Antithrombin
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[[1ant]], [[2ant]] – hAT – human
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**[[1att]] – AT-III – bovine
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[[1e05]] - hα-AT-III
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**[[1ant]], [[2ant]] – hAT – human
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[[1e04]] – hβ-AT-III
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**[[1e05]] - hα-AT-III
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[[1ath]], [[2znh]], [[4eb1]] – hAT-III
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**[[1e04]] – hβ-AT-III
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[[1dzg]], [[1oyh]], [[1t1f]], [[2beh]], [[2b4x]], [[2hij]] - hAT-III (mutant)
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**[[1ath]], [[2znh]], [[4eb1]] – hAT-III
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===Antithrombin binary complexes===
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**[[1dzg]], [[1oyh]], [[1t1f]], [[2beh]], [[2b4x]], [[2hij]] - hAT-III (mutant)
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[[1azx]], [[1nq9]], [[3evj]] – hAT + heparin pentasaccharide
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*Antithrombin binary complexes
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[[1e03]] – hα-AT-III + heparin pentasaccharide
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**[[1azx]], [[1nq9]], [[3evj]] – hAT + heparin pentasaccharide
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[[1dzh]] - hAT-III (mutant) + fluorescein
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**[[1e03]] – hα-AT-III + heparin pentasaccharide
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[[2gd4]] - hAT-III (mutant) + coagulation factor X
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**[[1dzh]] - hAT-III (mutant) + fluorescein
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[[1br8]], [[1jvq]], [[1lk6]], [[1r1l]] – hAT-III + peptide
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**[[2gd4]] - hAT-III (mutant) + coagulation factor X
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===Antithrombin ternary complexes===
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**[[1br8]], [[1jvq]], [[1lk6]], [[1r1l]] – hAT-III + peptide
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[[1sr5]] - hAT-III + prothrombin + heparin heptasaccharide
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*Antithrombin ternary complexes
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[[1tb6]] - hAT-III (mutant) + thrombin + heparin polysaccharide
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**[[1sr5]] - hAT-III + prothrombin + heparin heptasaccharide
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[[2b5t]] - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide
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**[[1tb6]] - hAT-III (mutant) + thrombin + heparin polysaccharide
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[[3kcg]] - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide
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**[[2b5t]] - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide
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**[[3kcg]] - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:31, 17 November 2014

Template:STRUCTURE 1tb6

Antithrombin (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.


3D structures of antithrombin

Updated on 17-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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