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Asparaginase
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *ASP I | |
| - | [[1hfj]], [[1hfk]], [[1o7j]] - ErcASP – ''Erwinia chrysanthemi''<br /> | + | **[[1hfj]], [[1hfk]], [[1o7j]] - ErcASP – ''Erwinia chrysanthemi''<br /> |
| - | [[1wnf]] - ASP – ''Pyrococcus horikoshii''<br /> | + | **[[1wnf]] - ASP – ''Pyrococcus horikoshii''<br /> |
| - | [[1zcf]] - PaASP – ''Pectobacterium atrosepticum''<br /> | + | **[[1zcf]] - PaASP – ''Pectobacterium atrosepticum''<br /> |
| - | [[2gez]] - ASP – yellow lupine<br /> | + | **[[2gez]] - ASP – yellow lupine<br /> |
| - | [[2ocd]] - ASP – ''Vibrio cholera''<br /> | + | **[[2ocd]] - ASP – ''Vibrio cholera''<br /> |
| - | [[2p2d]] - EcASP – ''Eschericia coli''<br /> | + | **[[2p2d]] - EcASP – ''Eschericia coli''<br /> |
| - | [[3ntx]] - ASP – ''Yersinia pestis''<br /> | + | **[[3ntx]] - ASP – ''Yersinia pestis''<br /> |
| - | [[3nxk]] - ASP – ''Campylobacter jejuni''<br /> | + | **[[3nxk]] - ASP – ''Campylobacter jejuni''<br /> |
| - | [[4gdu]] - hASP – human | + | **[[4gdu]] - hASP – human |
| - | + | *ASP I complex | |
| - | [[1hfw]] - ErcASP + glutamate<br /> | + | **[[1hfw]] - ErcASP + glutamate<br /> |
| - | [[2hln]] - PaASP + glutamate<br /> | + | **[[2hln]] - PaASP + glutamate<br /> |
| - | [[1hg0]] - ErcASP + succinate<br /> | + | **[[1hg0]] - ErcASP + succinate<br /> |
| - | [[1hg1]] - ErcASP + D-AA<BR /> | + | **[[1hg1]] - ErcASP + D-AA<BR /> |
| - | [[2gvn]] - PaSP + AA<BR /> | + | **[[2gvn]] - PaSP + AA<BR /> |
| - | [[2jk0]] - ASP + AA – ''Pectobacterium carotovorum''<br /> | + | **[[2jk0]] - ASP + AA – ''Pectobacterium carotovorum''<br /> |
| - | [[2wlt]], [[2wt4]] - ASP + AA – ''Helicobacter pylori''<br /> | + | **[[2wlt]], [[2wt4]] - ASP + AA – ''Helicobacter pylori''<br /> |
| - | [[2him]], [[2zal]] - EcASP + AA<BR /> | + | **[[2him]], [[2zal]] - EcASP + AA<BR /> |
| - | [[2p2n]] - EcASP + asparagine + AA<BR /> | + | **[[2p2n]] - EcASP + asparagine + AA<BR /> |
| - | [[1jsl]], [[1jsr]] - ErcASP + norleucine<br /> | + | **[[1jsl]], [[1jsr]] - ErcASP + norleucine<br /> |
| - | [[4gdt]] - hASP + malonate<br /> | + | **[[4gdt]] - hASP + malonate<br /> |
| - | [[4gdv]], [[4gdw]] - hASP + AA<BR /> | + | **[[4gdv]], [[4gdw]] - hASP + AA<BR /> |
| - | + | *ASP II | |
| - | [[1wsa]] – ASP precursor – ''Wolinella succinogenes''<br /> | + | **[[1wsa]] – ASP precursor – ''Wolinella succinogenes''<br /> |
| - | [[1ihd]], [[1jaz]], [[1jja]] - EcASP (mutant) | + | **[[1ihd]], [[1jaz]], [[1jja]] - EcASP (mutant) |
| - | + | *ASP II complex | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| + | **[[3eca]], [[4eca]], [[1nns]] – EcASP + AA<BR /> | ||
| + | **[[1ho3]] - EcASP (mutant) + AA<BR /> | ||
| + | **[[2zak]], [[3c17]] - EcASP precursor (mutant) | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:45, 18 November 2014
Asparaginase (ASP) catalyzes the conversion of asparagine to aspartic acid (AA). ASP I is used in the food processing industry to reduce the formation of the carcinogen acrylamide in the production of starchy food products. A different kind of ASP – ASP II – is used as drug (Elspar) in the treatment of cancer such as acute lymphoblastic leukemia (ALL). The ALL cells require high concentrations of asparagine which becomes scarce when high doses of ASP are present.
3D structures of asparaginase
Updated on 18-November-2014
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Michal Harel, Alexander Berchansky, Jaime Prilusky
