Beta-Hexosaminidase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[2xpk]], [[2w1n]] – CpBHEXB – ''Clostridium perfringens''<br />
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*Beta-hexoseaminidase
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[[2o4e]] – CpBHEXB - NMR<br />
+
-
[[2v5c]], [[2v5d]] – CpBHEXB catalytic domain<br />
+
-
[[2jh2]] – CpBHEXB cohesin-like module<br />
+
-
[[3gh4]] – PaBHEX – Paenibacillus<br />
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[[3bmx]] – BHEX – ''Bacillus subtilis''<br />
+
-
[[1tr9]] – VcBHEX – ''Vibrio cholerae''<br />
+
-
[[1hp4]] – SpBHEX – ''Streptomyces plicatus''<br />
+
-
[[2ltj]] – SpnBHEX G5 domain – ''Streptococcus pneumoniae'' – NMR<br />
+
-
[[2yl5]] – SpnBHEX residues 627-1064<br />
+
-
[[2yl6]], [[2yll]], [[3rpm]] – SpnBHEX catalytic domain<br />
+
-
[[1qba]] – SmBHEX – ''Serratia marcescens''<br />
+
-
[[3lmy]], [[1o7a]], [[1nou]] – hBHEXB β subunit – human<br />
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[[1o7a]] - hBHEXB β subunit<br />
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[[2gjx]] - hBHEXA α+β subunits<br />
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-
[[3nsm]] – OfBHEX residues 23-594 – ''Ostrinia furnacalis''<br />
+
-
[[4ais]] – BtBHEXB – ''Bacteroides thetaiotaomicron''<br />
+
-
[[4g6c]] – BcBHEX – ''Burkholderia cenocepacia''<br />
+
-
[[4gvg]] - SeBHEX – ''Salmonella enterica''<br />
+
-
[[3rcn]] – BHEX – ''Arthrobacter aurescens''
+
-
===Binary complexes===
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**[[2xpk]], [[2w1n]] – CpBHEXB – ''Clostridium perfringens''<br />
 +
**[[2o4e]] – CpBHEXB - NMR<br />
 +
**[[2v5c]], [[2v5d]] – CpBHEXB catalytic domain<br />
 +
**[[2jh2]] – CpBHEXB cohesin-like module<br />
 +
**[[3gh4]] – PaBHEX – Paenibacillus<br />
 +
**[[3bmx]] – BHEX – ''Bacillus subtilis''<br />
 +
**[[1tr9]] – VcBHEX – ''Vibrio cholerae''<br />
 +
**[1hp4]] – SpBHEX – ''Streptomyces plicatus''<br />
 +
**[[2ltj]] – SpnBHEX G5 domain – ''Streptococcus pneumoniae'' – NMR<br />
 +
**[[2yl5]] – SpnBHEX residues 627-1064<br />
 +
**[[2yl6]], [[2yll]], [[3rpm]] – SpnBHEX catalytic domain<br />
 +
**[[1qba]] – SmBHEX – ''Serratia marcescens''<br />
 +
**[[3lmy]], [[1o7a]], [[1nou]] – hBHEXB β subunit – human<br />
 +
**[[1o7a]] - hBHEXB β subunit<br />
 +
**[[2gjx]] - hBHEXA α+β subunits<br />
 +
**[[3nsm]] – OfBHEX residues 23-594 – ''Ostrinia furnacalis''<br />
 +
**[[4ais]] – BtBHEXB – ''Bacteroides thetaiotaomicron''<br />
 +
**[[4g6c]] – BcBHEX – ''Burkholderia cenocepacia''<br />
 +
**[[4gvg]] - SeBHEX – ''Salmonella enterica''<br />
 +
**[[3rcn]] – BHEX – ''Arthrobacter aurescens''
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[[2gk1]] - hBHEXA α+β subunits + NGT<br />
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*Beta-hexoseaminidase binary complexes
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[[1now]] - hBHEXB β subunit + GalNAc-isofagomine<br />
+
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[[1np0]] - hBHEXB β subunit + intermediate analog<br />
+
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[[3gh5]], [[3gh7]] - PaBHEX + GlcNAc<br />
+
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[[4gvf]], [[4gvh]], [[4gvi]] - SeBHEX + GlcNAc derivative<br />
+
-
[[4hzm]] – SeBHEX + inhibitor<br />
+
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[[1m01]] - SpBHEX + GlcNAc <br />
+
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[[1m03]], [[1m04]] - SpBHEX (mutant) + GlcNAc<br />
+
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[[1jak]] - SpBHEX + inhibitor<br />
+
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[[1hp5]] - SpBHEX + intermediate analog<br />
+
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[[2x0y]], [[2wb5]], [[2vur]] - CpBHEXB + inhibitor<br />
+
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[[2ozn]] – CpBHEXB + hyaluronidase<br />
+
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[[3ozo]] – OfBHEX residues 23-594 + NGT<br />
+
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[[3ozp]] – OfBHEX residues 23-594 + PUGNac<br />
+
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[[3nsn]] - OfBHEX residues 23-594 + chitotriomycin<br />
+
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[[2xj7]] – BtBHEXB + castanospermine <br />
+
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[[2wzh]], [[2wzi]] - BtBHEXB (mutant) + oxazoline<br />
+
-
[[2vvn]] - BtBHEX + thiazoline<br />
+
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[[2x0h]] - BtBHEXB Michaelis complex<br />
+
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[[2wca]], [[2vvs]] - BtBHEX + PUGNAc<br />
+
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[[2xm1]], [[2xm2]] - BtBHEXB + lactam derivative<br />
+
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[[4aiu]] - BtBHEXB + pyrazole derivative<br />
+
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[[2w66]], [[2w67]], [[2w4x]], [[2jiw]] – BtBHEXB + inhibitor<br />
+
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[[3gs6]], [[3gsm]], [[2oxn]] - VcBHEX + PUGNAc<br />
+
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[[1y65]] - VcBHEX + NAG<br />
+
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[[4gnv]] - BcBHEX + NAG<br />
+
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[[4mss]] – BcBHEX + inhibitor<br />
+
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[[2yl8]] – SpnBHEX catalytic domain (mutant) + NAG<br />
+
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[[4az5]], [[4az6]], [[4az7]], [[4az8]], [[4azc]], [[4azg]], [[4azh]] – SpnBHEX catalytic domain + inhibitor<br />
+
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[[4azi]] – SpnBHEX catalytic domain (mutant) + inhibitor<br />
+
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[[2yl9]], [[2yla]] – SpnBHEX residues 627-1062 (mutant) + NAG<br />
+
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[[1c7s]] – SmBHEX + diNAG <br />
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[[1c7t]] - SmBHEX (mutant) + diNAG<br />
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[[3sur]] - PaBHEX + NAG derivative<br />
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[[3sus]] - PaBHEX + GAL-NAG derivative<br />
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[[3sut]] - PaBHEX + PUGNac<br />
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[[3suu]] - PaBHEX + GAL-PUGNac<br />
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[[3suv]] - PaBHEX + NHAC-DNJ<br />
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[[3suw]] - PaBHEX + NHAC-CAS
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**[[2gk1]] - hBHEXA α+β subunits + NGT<br />
 +
**[[1now]] - hBHEXB β subunit + GalNAc-isofagomine<br />
 +
**[[1np0]] - hBHEXB β subunit + intermediate analog<br />
 +
**[[3gh5]], [[3gh7]] - PaBHEX + GlcNAc<br />
 +
**[[4gvf]], [[4gvh]], [[4gvi]] - SeBHEX + GlcNAc derivative<br />
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**[[4hzm]] – SeBHEX + inhibitor<br />
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**[[1m01]] - SpBHEX + GlcNAc <br />
 +
**[[1m03]], [[1m04]] - SpBHEX (mutant) + GlcNAc<br />
 +
**[[1jak]] - SpBHEX + inhibitor<br />
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**[[1hp5]] - SpBHEX + intermediate analog<br />
 +
**[[2x0y]], [[2wb5]], [[2vur]] - CpBHEXB + inhibitor<br />
 +
**[[2ozn]] – CpBHEXB + hyaluronidase<br />
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**[[3ozo]] – OfBHEX residues 23-594 + NGT<br />
 +
**[[3ozp]] – OfBHEX residues 23-594 + PUGNac<br />
 +
**[[3nsn]] - OfBHEX residues 23-594 + chitotriomycin<br />
 +
**[[2xj7]] – BtBHEXB + castanospermine <br />
 +
**[[2wzh]], [[2wzi]] - BtBHEXB (mutant) + oxazoline<br />
 +
**[[2vvn]] - BtBHEX + thiazoline<br />
 +
**[[2x0h]] - BtBHEXB Michaelis complex<br />
 +
**[[2wca]], [[2vvs]] - BtBHEX + PUGNAc<br />
 +
**[[2xm1]], [[2xm2]] - BtBHEXB + lactam derivative<br />
 +
**[[4aiu]] - BtBHEXB + pyrazole derivative<br />
 +
**[[2w66]], [[2w67]], [[2w4x]], [[2jiw]] – BtBHEXB + inhibitor<br />
 +
**[[3gs6]], [[3gsm]], [[2oxn]] - VcBHEX + PUGNAc<br />
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**[[1y65]] - VcBHEX + NAG<br />
 +
**[[4gnv]] - BcBHEX + NAG<br />
 +
**[[4mss]] – BcBHEX + inhibitor<br />
 +
**[[2yl8]] – SpnBHEX catalytic domain (mutant) + NAG<br />
 +
**[[4az5]], [[4az6]], [[4az7]], [[4az8]], [[4azc]], [[4azg]], [[4azh]] – SpnBHEX catalytic domain + inhibitor<br />
 +
**[[4azi]] – SpnBHEX catalytic domain (mutant) + inhibitor<br />
 +
**[[2yl9]], [[2yla]] – SpnBHEX residues 627-1062 (mutant) + NAG<br />
 +
**[[1c7s]] – SmBHEX + diNAG <br />
 +
**[[1c7t]] - SmBHEX (mutant) + diNAG<br />
 +
**[[3sur]] - PaBHEX + NAG derivative<br />
 +
**[[3sus]] - PaBHEX + GAL-NAG derivative<br />
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**[[3sut]] - PaBHEX + PUGNac<br />
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**[[3suu]] - PaBHEX + GAL-PUGNac<br />
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**[[3suv]] - PaBHEX + NHAC-DNJ<br />
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**[[3suw]] - PaBHEX + NHAC-CAS
 +
}}
==References==
==References==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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Revision as of 09:36, 19 November 2014

Human β-hexosaminidase (PDB code 2gjx)

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3D Structures of Beta-Hexosaminidase

Updated on 19-November-2014

References

  1. ↑ Lemieux MJ, Mark BL, Cherney MM, Withers SG, Mahuran DJ, James MN. Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. J Mol Biol. 2006 Jun 16;359(4):913-29. Epub 2006 Apr 27. PMID:16698036 doi:http://dx.doi.org/10.1016/j.jmb.2006.04.004
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