1mhw

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<StructureSection load='1mhw' size='340' side='right' caption='[[1mhw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1mhw' size='340' side='right' caption='[[1mhw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1mhw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1mhw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHW FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BP4:BIPHENYL-4-YLACETIC+ACID'>BP4</scene>, <scene name='pdbligand=CSW:CYSTEINE-S-DIOXIDE'>CSW</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=PEA:2-PHENYLETHYLAMINE'>PEA</scene></td></tr>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BP4:BIPHENYL-4-YLACETIC+ACID'>BP4</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=PEA:2-PHENYLETHYLAMINE'>PEA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cjl|1cjl]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cjl|1cjl]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhw RCSB], [http://www.ebi.ac.uk/pdbsum/1mhw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhw RCSB], [http://www.ebi.ac.uk/pdbsum/1mhw PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Cathepsin L]]
[[Category: Cathepsin L]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Chowdhury, S.]]
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[[Category: Chowdhury, S]]
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[[Category: Cygler, M.]]
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[[Category: Cygler, M]]
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[[Category: Devanathan, G.]]
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[[Category: Devanathan, G]]
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[[Category: Konishi, Y.]]
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[[Category: Konishi, Y]]
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[[Category: Lachance, P.]]
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[[Category: Lachance, P]]
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[[Category: Lefebvre, J.]]
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[[Category: Lefebvre, J]]
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[[Category: Menard, R.]]
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[[Category: Menard, R]]
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[[Category: Purisima, E O.]]
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[[Category: Purisima, E O]]
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[[Category: Qi, H.]]
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[[Category: Qi, H]]
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[[Category: Sivaraman, J.]]
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[[Category: Sivaraman, J]]
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[[Category: Sulea, T.]]
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[[Category: Sulea, T]]
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[[Category: Wang, J.]]
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[[Category: Wang, J]]
[[Category: Cathepsin l]]
[[Category: Cathepsin l]]
[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 10:06, 19 November 2014

Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides

1mhw, resolution 1.90Å

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