1mhw
From Proteopedia
(Difference between revisions)
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<StructureSection load='1mhw' size='340' side='right' caption='[[1mhw]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1mhw' size='340' side='right' caption='[[1mhw]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[1mhw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1mhw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MHW FirstGlance]. <br> |
- | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BP4:BIPHENYL-4-YLACETIC+ACID'>BP4</scene>, <scene name='pdbligand= | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BP4:BIPHENYL-4-YLACETIC+ACID'>BP4</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=PEA:2-PHENYLETHYLAMINE'>PEA</scene></td></tr> |
- | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cjl|1cjl]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cjl|1cjl]]</td></tr> |
- | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr> |
- | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhw RCSB], [http://www.ebi.ac.uk/pdbsum/1mhw PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mhw RCSB], [http://www.ebi.ac.uk/pdbsum/1mhw PDBsum]</span></td></tr> |
- | <table> | + | </table> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Cathepsin L]] | [[Category: Cathepsin L]] | ||
- | [[Category: | + | [[Category: Human]] |
- | [[Category: Chowdhury, S | + | [[Category: Chowdhury, S]] |
- | [[Category: Cygler, M | + | [[Category: Cygler, M]] |
- | [[Category: Devanathan, G | + | [[Category: Devanathan, G]] |
- | [[Category: Konishi, Y | + | [[Category: Konishi, Y]] |
- | [[Category: Lachance, P | + | [[Category: Lachance, P]] |
- | [[Category: Lefebvre, J | + | [[Category: Lefebvre, J]] |
- | [[Category: Menard, R | + | [[Category: Menard, R]] |
- | [[Category: Purisima, E O | + | [[Category: Purisima, E O]] |
- | [[Category: Qi, H | + | [[Category: Qi, H]] |
- | [[Category: Sivaraman, J | + | [[Category: Sivaraman, J]] |
- | [[Category: Sulea, T | + | [[Category: Sulea, T]] |
- | [[Category: Wang, J | + | [[Category: Wang, J]] |
[[Category: Cathepsin l]] | [[Category: Cathepsin l]] | ||
[[Category: Cysteine protease]] | [[Category: Cysteine protease]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] |
Revision as of 10:06, 19 November 2014
Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
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