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Cadherin

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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== CDH1 ===
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* CDH1
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[[1q1p]] – mCDH1 - mouse<br />
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**[[1q1p]] – mCDH1 - mouse<br />
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[[3q2v]] – mCDH1 ectodomain<br />
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**[[3q2v]] – mCDH1 ectodomain<br />
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[[3qrb]] – mCDH1+2
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**[[3qrb]] – mCDH1+2
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=== CDH5 ===
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* CDH5
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[[2koh]] – mCDH5+PAR3-PDZ3<br />
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**[[2koh]] – mCDH5+PAR3-PDZ3<br />
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=== CDH6 ===
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* CDH6
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[[3lnd]] – mCDH6 EC12 (mutant)<br />
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**[[3lnd]] – mCDH6 EC12 (mutant)<br />
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=== CDH8 ===
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* CDH8
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[[1zxk]] – mCDH8 EC1<br />
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**[[1zxk]] – mCDH8 EC1<br />
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[[2a62]] - mCDH8 EC1+EC2+EC3<br />
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**[[2a62]] - mCDH8 EC1+EC2+EC3<br />
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=== CDH11 ===
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* CDH11
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[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
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**[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
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=== CDH20 ===
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* CDH20
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[[1zvn]] – cCDH20 EC1 – chicken<br />
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**[[1zvn]] – cCDH20 EC1 – chicken<br />
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=== CDH23 ===
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* CDH23
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[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
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**[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
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[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
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**[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
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[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
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**[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
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[[2wbx]] – mCDH23 EC1<br />
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**[[2wbx]] – mCDH23 EC1<br />
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[[2wcp]] - mCDH23 EC2<br />
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**[[2wcp]] - mCDH23 EC2<br />
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[[2wd0]] - mCDH23 EC1+EC2 (mutant)<br />
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**[[2wd0]] - mCDH23 EC1+EC2 (mutant)<br />
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[[4apx]], [[4aq8]], [[4axw]] - mCDH23 EC1+EC2 + Prot-CDH15<br />
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**[[4apx]], [[4aq8]], [[4axw]] - mCDH23 EC1+EC2 + Prot-CDH15<br />
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[[4aqa]], [[4aqe]] - mCDH23 EC1+EC2 (mutant) + Prot-CDH15
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**[[4aqa]], [[4aqe]] - mCDH23 EC1+EC2 (mutant) + Prot-CDH15
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=== C-CDH “classical” ===
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* C-CDH “classical”
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[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
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**[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
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[[1q5b]], [[1q5c]], [[1q55]], [[1q5a]] – C-CDH model into desmosome – electron tomography<br />
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**[[1q5b]], [[1q5c]], [[1q55]], [[1q5a]] – C-CDH model into desmosome – electron tomography<br />
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=== E-CDH epithelial ===
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* E-CDH epithelial
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[[1ff5]] – mE-CDH double domain<br />
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**[[1edh]] - mE-CDH EC1+EC2+Ca<br />
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[[1edh]] - mE-CDH EC1+EC2+Ca<br />
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**[[3q2l]], [[3q2n]] - mE-CDH EC1+EC2 (mutant)<br />
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[[3q2l]], [[3q2n]] - mE-CDH EC1+EC2 (mutant)<br />
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**[[1suh]] – mE-CDH N-terminal - NMR<br />
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[[1suh]] – mE-CDH N-terminal - NMR<br />
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**[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br />
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[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br />
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**[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br />
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[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br />
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**[[2qvf]] – mE-CDH1 CDH2<br />
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[[2qvf]] – mE-CDH1 CDH2<br />
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**[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
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[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
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**[[2o72]] - hE-CDH EC1+EC2<br />
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[[2o72]] - hE-CDH EC1+EC2<br />
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**[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
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[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
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**[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
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[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
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**[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
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[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
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=== T-CDH membrane bound ===
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* T-CDH membrane bound
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[[3k5r]] – mT-CDH EC1+EC2<br />
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**[[3k5r]] – mT-CDH EC1+EC2<br />
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[[3k5s]] - cT-CDH EC1+EC2 <br />
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**[3k5s]] - cT-CDH EC1+EC2 <br />
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[[3k6d]] - XlT-CDH EC1 <br />
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**[[3k6d]] - XlT-CDH EC1 <br />
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[[3k6f]] - mT-CDH EC1<br />
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**[[3k6f]] - mT-CDH EC1<br />
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[[3k6i]] - cT-CDH EC1<br />
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**[[3k6i]] - cT-CDH EC1<br />
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[[2v37]] – hT-CDH N-terminal - NMR<br />
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**[[2v37]] – hT-CDH N-terminal - NMR<br />
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=== N-CDH neuronal ===
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* N-CDH neuronal
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[[1nch]], [[1nci]] – mN-CDH<br />
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**[[1nch]], [[1nci]] – mN-CDH<br />
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[[1ncg]] – mN-CDH (mutant)<br />
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**[[1ncg]] – mN-CDH (mutant)<br />
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[[2qvi]] – mN-CDH EC12<br />
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**[[1ncj]] – mN-CDH two domains<br />
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[[1ncj]] – mN-CDH two domains<br />
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**[[3q2w]] – mN-CDH ectodomain<br />
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[[3q2w]] – mN-CDH ectodomain<br />
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**[[1op4]] - mN-CDH prodomain - NMR<br />
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[[1op4]] - mN-CDH prodomain - NMR<br />
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**[[3ubf]] – DmN-CDH ectodomain – ''Drosophila melanogaster''<br />
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[[3ubf]] – DmN-CDH ectodomain – ''Drosophila melanogaster''<br />
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**[[3ubh]] - DmN-CDH EC1-4<br />
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[[3ubh]] - DmN-CDH EC1-4<br />
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**[[3ubg]] - DmN-CDH EC1-3
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[[3ubg]] - DmN-CDH EC1-
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===VE-CDH vascular epithelial===
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*VE-CDH vascular epithelial
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[[3ppe]] – cVE-CDH EC1+EC2<br />
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**[[3ppe]] – cVE-CDH EC1+EC2<br />
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=== Protocadherin ===
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* Protocadherin
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[[2yst]] – hProt-CDH7 EC3 – NMR<br />
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**[[2yst]] – hProt-CDH7 EC3 – NMR<br />
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[[2ee0]] - hProt-CDH9 Ca domain – NMR<br />
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**[[2ee0]] - hProt-CDH9 Ca domain – NMR<br />
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[[1wyj]] - mProt-CDH β 14 - NMR<br />
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**[[1wyj]] - mProt-CDH β 14 - NMR<br />
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[[1wuz]] - mProt-CDH4 EC1 – NMR
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**[[1wuz]] - mProt-CDH4 EC1 – NMR
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=== Desmoglein ===
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* Desmoglein
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[[2yqg]] – hDes-CDH EC1<br />
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**[[2yqg]] – hDes-CDH EC1<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:16, 19 November 2014

Template:STRUCTURE 1q1p

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. Calcium ions are shown as a space filling objects.

3D Structures of Cadherin

Updated on 19-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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