1la2

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[[Image:1la2.gif|left|200px]]<br /><applet load="1la2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1la2.gif|left|200px]]
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caption="1la2, resolution 2.65&Aring;" />
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'''Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase'''<br />
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{{Structure
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|PDB= 1la2 |SIZE=350|CAPTION= <scene name='initialview01'>1la2</scene>, resolution 2.65&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Inositol-3-phosphate_synthase Inositol-3-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.4 5.5.1.4]
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|GENE= INO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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}}
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'''Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LA2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=NAD:'>NAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Inositol-3-phosphate_synthase Inositol-3-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.4 5.5.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LA2 OCA].
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1LA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LA2 OCA].
==Reference==
==Reference==
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Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase., Kniewel R, Buglino JA, Shen V, Chadha T, Beckwith A, Lima CD, J Struct Funct Genomics. 2002;2(3):129-34. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12836703 12836703]
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Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase., Kniewel R, Buglino JA, Shen V, Chadha T, Beckwith A, Lima CD, J Struct Funct Genomics. 2002;2(3):129-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12836703 12836703]
[[Category: Inositol-3-phosphate synthase]]
[[Category: Inositol-3-phosphate synthase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: yeast]]
[[Category: yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:42:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:28:29 2008''

Revision as of 10:28, 20 March 2008

Image:1la2.gif


PDB ID 1la2

Drag the structure with the mouse to rotate
, resolution 2.65Å
Ligands:
Gene: INO1 (Saccharomyces cerevisiae)
Activity: Inositol-3-phosphate synthase, with EC number 5.5.1.4
Coordinates: save as pdb, mmCIF, xml



Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase


Overview

The New York Structural Genomics Research Consortium has targeted highly conserved but uncharacterized enzyme families for structure determination. As part of this effort, the 2.65-A crystal structure has been determined for Saccharomyces cerevisiae myo-inositol 1-phosphate synthase (MIP), an essential enzyme that catalyzes critical steps in inositol biosynthesis. The structure determination of four independent monomers in the asymmetric unit (240 kDa) reveals atomic details and residue composition for the partially closed NAD-containing active sites in apo-configuration. The structure further reveals extensive interactions involved in tetrameric assembly of the enzyme complex.

About this Structure

1LA2 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase., Kniewel R, Buglino JA, Shen V, Chadha T, Beckwith A, Lima CD, J Struct Funct Genomics. 2002;2(3):129-34. PMID:12836703

Page seeded by OCA on Thu Mar 20 12:28:29 2008

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