1lbe

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[[Image:1lbe.gif|left|200px]]<br /><applet load="1lbe" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lbe.gif|left|200px]]
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caption="1lbe, resolution 2.4&Aring;" />
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'''APLYSIA ADP RIBOSYL CYCLASE'''<br />
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{{Structure
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|PDB= 1lbe |SIZE=350|CAPTION= <scene name='initialview01'>1lbe</scene>, resolution 2.4&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5]
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|GENE=
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}}
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'''APLYSIA ADP RIBOSYL CYCLASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LBE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Active as [http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBE OCA].
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1LBE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBE OCA].
==Reference==
==Reference==
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Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38., Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD, Nat Struct Biol. 1996 Nov;3(11):957-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8901875 8901875]
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Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38., Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD, Nat Struct Biol. 1996 Nov;3(11):957-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8901875 8901875]
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
[[Category: NAD(+) nucleosidase]]
[[Category: NAD(+) nucleosidase]]
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[[Category: nadase]]
[[Category: nadase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:43:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:28:57 2008''

Revision as of 10:29, 20 March 2008

Image:1lbe.gif


PDB ID 1lbe

Drag the structure with the mouse to rotate
, resolution 2.4Å
Activity: NAD(+) nucleosidase, with EC number 3.2.2.5
Coordinates: save as pdb, mmCIF, xml



APLYSIA ADP RIBOSYL CYCLASE


Overview

ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize cADPR. The crystal structure provides a model for these cell surface enzymes. Cyclase contains two spatially separated pockets composed of sequence conserved residues, suggesting that the cyclization reaction may entail use of distinct sites. The enzyme dimer encloses a cavity which may entrap the intermediate, ADP ribose.

About this Structure

1LBE is a Single protein structure of sequence from Aplysia californica. Full crystallographic information is available from OCA.

Reference

Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38., Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD, Nat Struct Biol. 1996 Nov;3(11):957-64. PMID:8901875

Page seeded by OCA on Thu Mar 20 12:28:57 2008

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