1lc6
From Proteopedia
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| - | [[Image:1lc6.gif|left|200px]] | + | [[Image:1lc6.gif|left|200px]] |
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| - | '''Solution Structure of the U6 Intramolecular Stem-loop RNA''' | + | {{Structure |
| + | |PDB= 1lc6 |SIZE=350|CAPTION= <scene name='initialview01'>1lc6</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution Structure of the U6 Intramolecular Stem-loop RNA''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LC6 is a [ | + | 1LC6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA]. |
==Reference== | ==Reference== | ||
| - | Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:[http:// | + | Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11992125 11992125] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Allmann, A M.]] | [[Category: Allmann, A M.]] | ||
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[[Category: stem-loop]] | [[Category: stem-loop]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:29:11 2008'' |
Revision as of 10:29, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of the U6 Intramolecular Stem-loop RNA
Overview
U6 RNA is a key component of the catalytic core of the spliceosome. A metal ion essential for the first catalytic step of pre-mRNA splicing binds to the U80 Sp phosphate oxygen within the yeast U6 intramolecular stem-loop (ISL). Here we present the first structural data for U6 RNA, revealing the three-dimensional structure of the highly conserved U6 ISL. The ISL binds metal ion at the U80 site with the same stereo specificity as the intact spliceosome. The metal-binding site is adjacent to a readily protonated C.A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing.
About this Structure
1LC6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:11992125
Page seeded by OCA on Thu Mar 20 12:29:11 2008
