Casein kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===CK1===
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*CK1
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[[2c47]] – hCK1-γ2 – human
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**[[2c47]] – hCK1-γ2 – human<br />
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**[[2chl]] - hCK1-γ3<br />
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**[[2cmw]] – hCK1-γ1 + inhibitor<br />
 +
**[[2izr]], [[2izs]], [[2izs]], [[2izu]], [[2izt]], [[4g16]], [[4g17]], [[4hgl]], [[4hgs]] - hCK1-γ3 + inhibitor<br />
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**[[3uys]] – hCK1-δ<br />
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**[[3uyt]], [[3uzp]], [[4hgt]], [[4hnf]], [[4kb8]], [[4kba]], [[4kbc]], [[4kbk]] – hCK1-δ + inhibitor<br />
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**[1cki]] – rCK1-δ (mutant) – rat<br />
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**[[1ckj]] - rCK1-δ (mutant) + WO4<br />
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**[[4jjr]] - CK1-δ - mouse<br />
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**[[4hok]] - hCK1-ε <br />
 +
**[[4hni]] - hCK1-ε + inhibitor<br />
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**[[1csn]] – yCK1 + MgATP – fission yeast<br />
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**[[2csn]], [[1eh4]] – yCK1 catalytic domain + inhibitor
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[[2chl]] - hCK1-γ3
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*CK2 catalytic subunit
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[[2cmw]] – hCK1-γ1 + inhibitor
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**[[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]] - hCK2 α subunit <br />
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**[[1na7]], [[3fwq]], [[3juh]] - hCK2 α subunit (mutant)<br />
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**[[3axw]], [[3r0t]], [[3u4u]] – hCK2 α subunit + inhibitor<br />
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**[[3u87]] – hCK2 α subunit + ATP analog<br />
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**[[3q9w]], [[3q9x]] – hCK2 α subunit + emodin<br />
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**[[3q9y]], [[3q9z]] – hCK2 α subunit + quinalizarin<br />
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**[[3u9c]] – hCK2 α subunit + resorufin<br />
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**[[3ofm]] - hCK2 α’ subunit <br />
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**[[2r7i]] - rCK2 α subunit <br />
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**[[1lpu]], [[1lr4]], [[1jam]] - mCK2 α subunit <br />
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**[[1daw]], [[1day]] – mCK2 + Mg-AMPPNP <br />
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**[[1f0q]], [[3pzh]] – mCK2 α subunit + emodin<br />
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**[[1zoe]], [[1zog]], [[1zoh]] – mCK2 α subunit + TBB derivative<br />
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[[2izr]], [[2izs]], [[2izs]], [[2izu]], [[2izt]], [[4g16]], [[4g17]], [[4hgl]], [[4hgs]] - hCK1-γ3 + inhibitor<br />
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*CK2 catalytic subunit binary complex
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[[3uys]] – hCK1-δ<br />
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-
[[3uyt]], [[3uzp]], [[4hgt]], [[4hnf]], [[4kb8]], [[4kba]], [[4kbc]], [[4kbk]] – hCK1-δ + inhibitor<br />
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-
[[1cki]] – rCK1-δ (mutant) – rat
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-
[[1ckj]] - rCK1-δ (mutant) + WO4<br />
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**[[2pvr]] - hCK2 α subunit + sulfate<br />
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[[4jjr]] - CK1-δ - mouse<br />
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**[[3rp0]] – hCK2 α subunit + α’ subunit + ATP analog
-
[[4hok]] - hCK1-ε <br />
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-
[[4hni]] - hCK1-ε + inhibitor<br />
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-
[[1csn]] – yCK1 + MgATP – fission yeast
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-
[[2csn]], [[1eh4]] – yCK1 catalytic domain + inhibitor
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**[[3bqc]], [[3c13]] - hCK2 α subunit + emodin
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===CK2 catalytic subunit===
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**[[1j91]] - mCK2 α subunit + ATP competitive inhibitor - maize
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[[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]] - hCK2 α subunit
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**[[1lp4]] - mCK2 α subunit + Mg-AMPPNP
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[[1na7]], [[3fwq]], [[3juh]] - hCK2 α subunit (mutant)<br />
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**[[3nsz]] - hCK2 α subunit + AMPPN<br />
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[[3axw]], [[3r0t]], [[3u4u]] – hCK2 α subunit + inhibitor<br />
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**[[3w8l]] - hCK2 α subunit (mutant) + inositol hexakisphosphate<br />
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[[3u87]] – hCK2 α subunit + ATP analog<br />
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**[[4dgm]] - mCK2 α subunit + apigenin<br />
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[[3q9w]], [[3q9x]] – hCK2 α subunit + emodin<br />
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**[[4dgn]] - mCK2 α subunit + luteolin<br />
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[[3q9y]], [[3q9z]] – hCK2 α subunit + quinalizarin<br />
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**[[4dgo]] - mCK2 α subunit + tyrphostin<br />
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[[3u9c]] – hCK2 α subunit + resorufin<br />
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**[[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]], [[3pwd]] - mCK2 α subunit + inhibitor
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[[3ofm]] - hCK2 α’ subunit
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[[2r7i]] - rCK2 α subunit
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**[[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]], [[3at3]], [[3at4]], [[4anm]], [[4grb]], [[4gub]] - hCK2 α subunit + inhibitor<br />
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**[[4fbx]] - hCK2 α subunit + polypeptide inhibitor<br />
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**[[4ib5]] - hCK2 α subunit + hCK2 β polypeptide <br />
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**[[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 α subunit (mutant) + inhibitor<br />
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**[[4fi1]], [[4mwh]] - yCK2 α subunit + ATP<br />
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[[1lpu]], [[1lr4]], [[1jam]] - mCK2 α subunit <br />
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*CK2 regulatory subunit
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[[1daw]], [[1day]] – mCK2 + Mg-AMPPNP <br />
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-
[[1f0q]], [[3pzh]] – mCK2 α subunit + emodin<br />
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-
[[1zoe]], [[1zog]], [[1zoh]] – mCK2 α subunit + TBB derivative<br />
+
-
===CK2 catalytic subunit binary complex===
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**[[1qf8]], [[3eed]] – hCK2 β subunit
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[[2pvr]] - hCK2 α subunit + sulfate
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**[[2r6m]] - rCK2 β subunit
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[[3rp0]] – hCK2 α subunit + α’ subunit + ATP analog
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**[[1rqf]] - CK2 β subunit + cyclin-dependent kinase peptide – ''Xenopus laevis''
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[[3bqc]], [[3c13]] - hCK2 α subunit + emodin
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*CK2 catalytic + regulatory subunits
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+
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[[1j91]] - mCK2 α subunit + ATP competitive inhibitor - maize
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-
 
+
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[[1lp4]] - mCK2 α subunit + Mg-AMPPNP
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-
 
+
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[[3nsz]] - hCK2 α subunit + AMPPN<br />
+
-
[[3w8l]] - hCK2 α subunit (mutant) + inositol hexakisphosphate<br />
+
-
[[4dgm]] - mCK2 α subunit + apigenin<br />
+
-
[[4dgn]] - mCK2 α subunit + luteolin<br />
+
-
[[4dgo]] - mCK2 α subunit + tyrphostin<br />
+
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[[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]], [[3pwd]] - mCK2 α subunit + inhibitor
+
-
 
+
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[[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]], [[3at3]], [[3at4]], [[4anm]], [[4grb]], [[4gub]] - hCK2 α subunit + inhibitor<br />
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[[4fbx]] - hCK2 α subunit + polypeptide inhibitor<br />
+
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[[4ib5]] - hCK2 α subunit + hCK2 β polypeptide <br />
+
-
[[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 α subunit (mutant) + inhibitor<br />
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[[4fi1]], [[4mwh]] - yCK2 α subunit + ATP<br />
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-
 
+
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===CK2 regulatory subunit===
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-
 
+
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[[1qf8]], [[3eed]] – hCK2 β subunit
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-
 
+
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[[2r6m]] - rCK2 β subunit
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-
 
+
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[[1rqf]] - CK2 β subunit + cyclin-dependent kinase peptide – ''Xenopus laevis''
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-
 
+
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===CK2 catalytic + regulatory subunits===
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-
 
+
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[[1jwh]], [[4md7]] - hCK2 α subunit + β subunit<br />
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-
[[4dgl]], [[4md8]], [[4md9]] - hCK2 α subunit (mutant) + β subunit<br />
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[[1ds5]] - mCK2 α subunit + β subunit peptide
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**[[1jwh]], [[4md7]] - hCK2 α subunit + β subunit<br />
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**[[4dgl]], [[4md8]], [[4md9]] - hCK2 α subunit (mutant) + β subunit<br />
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**[[1ds5]] - mCK2 α subunit + β subunit peptide
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:49, 19 November 2014

Template:STRUCTURE 3mb6

Casein kinase (CK) is a protein kinase which functions as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one.


3D Structures of casein kinase

Updated on 19-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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