3duz

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[[Image:3duz.png|left|200px]]
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==Crystal structure of the postfusion form of baculovirus fusion protein GP64==
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<StructureSection load='3duz' size='340' side='right' caption='[[3duz]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3duz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DUZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GP67, P67 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46015 Autographa californica nucleopolyhedrovirus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3duz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3duz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3duz RCSB], [http://www.ebi.ac.uk/pdbsum/3duz PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/3duz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Viral fusion proteins mediate the merger of host and viral membranes during cell entry for all enveloped viruses. Baculovirus glycoprotein gp64 (gp64) is unusual in promoting entry into both insect and mammalian cells and is distinct from established class I and class II fusion proteins. We report the crystal structure of its postfusion form, which explains a number of gp64's biological properties including its cellular promiscuity, identifies the fusion peptides and shows it to be the third representative of a new class (III) of fusion proteins with unexpected structural homology with vesicular stomatitis virus G and herpes simplex virus type 1 gB proteins. We show that domains of class III proteins have counterparts in both class I and II proteins, suggesting that all these viral fusion machines are structurally more related than previously thought.
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{{STRUCTURE_3duz| PDB=3duz | SCENE= }}
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The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines.,Kadlec J, Loureiro S, Abrescia NG, Stuart DI, Jones IM Nat Struct Mol Biol. 2008 Oct;15(10):1024-30. Epub 2008 Sep 7. PMID:18776902<ref>PMID:18776902</ref>
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===Crystal structure of the postfusion form of baculovirus fusion protein GP64===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18776902}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3duz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DUZ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018776902</ref><references group="xtra"/>
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[[Category: Autographa californica nucleopolyhedrovirus]]
[[Category: Autographa californica nucleopolyhedrovirus]]
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[[Category: Abrescia, N G.A.]]
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[[Category: Abrescia, N G.A]]
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[[Category: Jones, I M.]]
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[[Category: Jones, I M]]
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[[Category: Kadlec, J.]]
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[[Category: Kadlec, J]]
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[[Category: Loureiro, S.]]
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[[Category: Loureiro, S]]
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[[Category: Stuart, D I.]]
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[[Category: Stuart, D I]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
[[Category: Fusion peptide]]
[[Category: Fusion peptide]]

Revision as of 13:12, 19 November 2014

Crystal structure of the postfusion form of baculovirus fusion protein GP64

3duz, resolution 2.95Å

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