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1lev

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[[Image:1lev.jpg|left|200px]]<br /><applet load="1lev" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lev.jpg|left|200px]]
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caption="1lev, resolution 2.15&Aring;" />
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'''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''<br />
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{{Structure
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|PDB= 1lev |SIZE=350|CAPTION= <scene name='initialview01'>1lev</scene>, resolution 2.15&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=CLI:3-(2-CARBOXY-ETHYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID'>CLI</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11]
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|GENE=
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}}
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'''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LEV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=F6P:'>F6P</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=CLI:'>CLI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEV OCA].
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1LEV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEV OCA].
==Reference==
==Reference==
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3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site., Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12781194 12781194]
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3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site., Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12781194 12781194]
[[Category: Fructose-bisphosphatase]]
[[Category: Fructose-bisphosphatase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:44:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:30:15 2008''

Revision as of 10:30, 20 March 2008

Image:1lev.jpg


PDB ID 1lev

Drag the structure with the mouse to rotate
, resolution 2.15Å
Ligands: , and
Activity: Fructose-bisphosphatase, with EC number 3.1.3.11
Coordinates: save as pdb, mmCIF, xml



PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR


Overview

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design.

About this Structure

1LEV is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site., Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID:12781194

Page seeded by OCA on Thu Mar 20 12:30:15 2008

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