Catabolite gene activator protein
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *CAP | |
| - | [[3d0s]] – MtCAP – ''Mycobacterium tuberculosis'' <br /> | + | **[[3d0s]] – MtCAP – ''Mycobacterium tuberculosis'' <br /> |
| - | [[2wc2]] – EcCAP – ''Escherichia coli'' - NMR<br /> | + | **[[2wc2]] – EcCAP – ''Escherichia coli'' - NMR<br /> |
| - | [[3hif]], [[4ft8]], [[4hzf]] – EcCAP <br /> | + | **[[3hif]], [[4ft8]], [[4hzf]] – EcCAP <br /> |
| - | [[3fwe]], [[4bh9]], [[4bhp]] – EcCAP (mutant) <br /> | + | **[[3fwe]], [[4bh9]], [[4bhp]] – EcCAP (mutant) <br /> |
| - | + | *CAP complex with cAMP | |
| - | [[1g6n]], [[1i5z]], [[2gzw]], [[3ryp]], [[3ryr]], [[4i01]], [[4i02]], [[4i09]], [[4i0a]], [[4i0b]] – EcCAP + cAMP <br /> | + | **[[1g6n]], [[1i5z]], [[2gzw]], [[3ryp]], [[3ryr]], [[4i01]], [[4i02]], [[4i09]], [[4i0a]], [[4i0b]] – EcCAP + cAMP <br /> |
| - | [[1hw5]], [[1i6x]], [[3kcc]], [[3qop]], [[3rdi]], [[3rou]], [[3rpq]] – EcCAP (mutant) + cAMP <br /> | + | **[[1hw5]], [[1i6x]], [[3kcc]], [[3qop]], [[3rdi]], [[3rou]], [[3rpq]] – EcCAP (mutant) + cAMP <br /> |
| - | [[3i54]], [[3i59]] – MtCAP + cAMP <br /> | + | **[[3i54]], [[3i59]] – MtCAP + cAMP <br /> |
| - | + | *CAP complex with cAMP and DNA | |
| - | [[1cgp]], [[1run]], [[2cgp]], [[1j59]], [[1o3q]], [[1o3r]], [[1o3s]], [[1o3t]], [[1zrc]], [[1zrd]], [[1zre]], [[1zrf]] – EcCAP + cAMP + DNA <br /> | + | **[[1cgp]], [[1run]], [[2cgp]], [[1j59]], [[1o3q]], [[1o3r]], [[1o3s]], [[1o3t]], [[1zrc]], [[1zrd]], [[1zre]], [[1zrf]] – EcCAP + cAMP + DNA <br /> |
| - | [[1ruo]] – EcCAP (mutant) + cAMP + DNA <br /> | + | **[[1ruo]] – EcCAP (mutant) + cAMP + DNA <br /> |
| - | + | *CAP complex with cAMP, DNA and DNA directed polymerase | |
| - | [[1lb2]], [[3n4m]] – EcCAP + cAMP + DNA + DNA-directed RNA polymerase α subunit<br /> | + | **[[1lb2]], [[3n4m]] – EcCAP + cAMP + DNA + DNA-directed RNA polymerase α subunit<br /> |
| - | [[3iyd]] – EcCAP + cAMP + DNA + DNA-directed RNA polymerase α, β, ω subunits + RNA polymerase σ factor – Cryo EM<br /> | + | **[[3iyd]] – EcCAP + cAMP + DNA + DNA-directed RNA polymerase α, β, ω subunits + RNA polymerase σ factor – Cryo EM<br /> |
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:15, 19 November 2014
Catabolite gene activator protein (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. Two cAMP molecules bind to the dimeric CAP. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes.
3D Structures of catabolite gene activator protein
Updated on 19-November-2014
