3e3u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3e3u" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3e3u.png|left|200px]]
+
==Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor==
 +
<StructureSection load='3e3u' size='340' side='right' caption='[[3e3u]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3e3u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E3U FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=NVC:N-[(2R)-2-{[(2S)-2-(1,3-BENZOXAZOL-2-YL)PYRROLIDIN-1-YL]CARBONYL}HEXYL]-N-HYDROXYFORMAMIDE'>NVC</scene></td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">def ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
 +
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e3u RCSB], [http://www.ebi.ac.uk/pdbsum/3e3u PDBsum]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/3e3u_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Bacterial peptide deformylase (PDF) belongs to a subfamily of metalloproteases catalyzing the removal of the N-terminal formyl group from newly synthesized proteins. We report the synthesis and biological activity of highly potent inhibitors of Mycobacterium tuberculosis (Mtb) PDF enzyme as well as the first X-ray crystal structure of Mtb PDF. Structure-activity relationship and crystallographic data clarified the structural requirements for high enzyme potency and cell based potency. Activities against single and multi-drug-resistant Mtb strains are also reported.
-
{{STRUCTURE_3e3u| PDB=3e3u | SCENE= }}
+
Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results.,Pichota A, Duraiswamy J, Yin Z, Keller TH, Alam J, Liung S, Lee G, Ding M, Wang G, Chan WL, Schreiber M, Ma I, Beer D, Ngew X, Mukherjee K, Nanjundappa M, Teo JW, Thayalan P, Yap A, Dick T, Meng W, Xu M, Koehn J, Pan SH, Clark K, Xie X, Shoen C, Cynamon M Bioorg Med Chem Lett. 2008 Dec 15;18(24):6568-72. Epub 2008 Oct 14. PMID:19008098<ref>PMID:19008098</ref>
-
===Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_19008098}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[3e3u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3U OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:019008098</ref><references group="xtra"/>
+
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Peptide deformylase]]
[[Category: Peptide deformylase]]
-
[[Category: Koehn, J.]]
+
[[Category: Koehn, J]]
-
[[Category: Meng, W.]]
+
[[Category: Meng, W]]
-
[[Category: Pan, S.]]
+
[[Category: Pan, S]]
-
[[Category: Xu, M.]]
+
[[Category: Xu, M]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Iron]]
[[Category: Iron]]

Revision as of 13:16, 19 November 2014

Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor

3e3u, resolution 1.56Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3e3u"
Personal tools