1lg7
From Proteopedia
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| - | [[Image:1lg7.jpg|left|200px]] | + | [[Image:1lg7.jpg|left|200px]] |
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| - | '''Crystal structure of Vesicular Stomatitis Virus Matrix Protein''' | + | {{Structure |
| + | |PDB= 1lg7 |SIZE=350|CAPTION= <scene name='initialview01'>1lg7</scene>, resolution 1.96Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal structure of Vesicular Stomatitis Virus Matrix Protein''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LG7 is a [ | + | 1LG7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LG7 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of vesicular stomatitis virus matrix protein., Gaudier M, Gaudin Y, Knossow M, EMBO J. 2002 Jun 17;21(12):2886-92. PMID:[http:// | + | Crystal structure of vesicular stomatitis virus matrix protein., Gaudier M, Gaudin Y, Knossow M, EMBO J. 2002 Jun 17;21(12):2886-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12065402 12065402] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vesicular stomatitis virus]] | [[Category: Vesicular stomatitis virus]] | ||
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[[Category: virus matrix]] | [[Category: virus matrix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:30:33 2008'' |
Revision as of 10:30, 20 March 2008
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| , resolution 1.96Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Vesicular Stomatitis Virus Matrix Protein
Overview
The vesicular stomatitis virus (VSV) matrix protein (M) interacts with cellular membranes, self-associates and plays a major role in virus assembly and budding. We present the crystallographic structure, determined at 1.96 A resolution, of a soluble thermolysin resistant core of VSV M. The fold is a new fold shared by the other vesiculovirus matrix proteins. The structure accounts for the loss of stability of M temperature-sensitive mutants deficient in budding, and reveals a flexible loop protruding from the globular core that is important for self-assembly. Membrane floatation shows that, together with the M lysine-rich N-terminal peptide, a second domain of the protein is involved in membrane binding. Indeed, the structure reveals a hydrophobic surface located close to the hydrophobic loop and surrounded by conserved basic residues that may constitute this domain. Lastly, comparison of the negative-stranded virus matrix proteins with retrovirus Gag proteins suggests that the flexible link between their major membrane binding domain and the rest of the structure is a common feature shared by these proteins involved in budding and virus assembly.
About this Structure
1LG7 is a Single protein structure of sequence from Vesicular stomatitis virus. Full crystallographic information is available from OCA.
Reference
Crystal structure of vesicular stomatitis virus matrix protein., Gaudier M, Gaudin Y, Knossow M, EMBO J. 2002 Jun 17;21(12):2886-92. PMID:12065402
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