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3eb8

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[[Image:3eb8.png|left|200px]]
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==VirA==
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<StructureSection load='3eb8' size='340' side='right' caption='[[3eb8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3eb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EB8 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">virA, CP0181, pWR501_0191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 Shigella flexneri])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eb8 RCSB], [http://www.ebi.ac.uk/pdbsum/3eb8 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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VirA, an essential virulence factor in Shigella disease pathogenesis, is involved in the uptake, motility, and cell-to-cell spread of Shigella organisms within the human host. These functions have been attributed to a VirA protease activity and a mechanism of microtubule destruction via tubulin degradation [Yoshida, S., et al. (2006) Science 314, 985-989]. We report functional and crystallographic data indicating a novel VirA structure that lacks these activities but highlights the homology to the EspG virulence factor of pathogenic Escherichia coli.
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{{STRUCTURE_3eb8| PDB=3eb8 | SCENE= }}
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Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.,Germane KL, Ohi R, Goldberg MB, Spiller BW Biochemistry. 2008 Sep 30;47(39):10241-3. Epub 2008 Sep 3. PMID:18763811<ref>PMID:18763811</ref>
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===VirA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18763811}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3eb8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB8 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018763811</ref><references group="xtra"/>
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[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Germane, K L.]]
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[[Category: Germane, K L]]
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[[Category: Spiller, B W.]]
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[[Category: Spiller, B W]]
[[Category: Alpha helix]]
[[Category: Alpha helix]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]

Revision as of 13:21, 19 November 2014

VirA

3eb8, resolution 2.40Å

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