3eil

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[[Image:3eil.png|left|200px]]
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==Structure of B-DNA d(CGTTAATTAACG)2 in the presence of Manganese==
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<StructureSection load='3eil' size='340' side='right' caption='[[3eil]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3eil]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eil OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eil RCSB], [http://www.ebi.ac.uk/pdbsum/3eil PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present the structure of the duplex formed by a fragment of auto-complementary DNA with the sequence d(CGTTAATTAACG). The structure was determined by X-ray crystallography. Up to date it is the first structure presenting the interaction between a DNA oligonucleotide and manganese ions. The presence of Mn2+ creates bonds among the N7 atom of guanines and phosphates. These bonds stabilize and determine the crystallographic network in a P3(2) space group, unusual in oligonucleotide crystals. The crystal structure observed is compared with those found in the presence of Mg2+, Ca2+ and Ni2+, which show different kinds of interactions. The double helices show end-to-end interactions, in a manner that the terminal guanines interact with the minor groove of the neighboring duplex, while the terminal cytosines are disordered. We have chosen this sequence since it contains a TTAA repeat. Such repeats are very rare in all genomes. We suggest that this sequence may be very susceptible to the formation of closely spaced thymine dimers.
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{{STRUCTURE_3eil| PDB=3eil | SCENE= }}
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The interaction of manganese ions with DNA.,Millonig H, Pous J, Gouyette C, Subirana JA, Campos JL J Inorg Biochem. 2009 Jun;103(6):876-80. Epub 2009 Mar 25. PMID:19375803<ref>PMID:19375803</ref>
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===Structure of B-DNA d(CGTTAATTAACG)2 in the presence of Manganese===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19375803}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3eil]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIL OCA].
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</StructureSection>
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[[Category: Campos, L J]]
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==Reference==
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[[Category: Millonig, H]]
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<ref group="xtra">PMID:019375803</ref><references group="xtra"/>
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[[Category: Pous, J]]
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[[Category: Campos, L J.]]
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[[Category: Subirana, J A]]
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[[Category: Millonig, H.]]
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[[Category: Pous, J.]]
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[[Category: Subirana, J A.]]
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[[Category: B-dna]]
[[Category: B-dna]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Manganese]]
[[Category: Manganese]]

Revision as of 13:22, 19 November 2014

Structure of B-DNA d(CGTTAATTAACG)2 in the presence of Manganese

3eil, resolution 2.60Å

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