3ee9
From Proteopedia
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| - | [[ | + | ==Structure of NS1 effector domain== |
| + | <StructureSection load='3ee9' size='340' side='right' caption='[[3ee9]], [[Resolution|resolution]] 2.14Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ee9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EE9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ee8|3ee8]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ee9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ee9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ee9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional domains: an N-terminal 73-amino-acid RNA-binding domain and a C-terminal effector domain. Here, the crystallographic structure of the NS1A effector domain of influenza A/Udorn/72 virus is presented. Structure comparison with the NS1 effector domain from mouse-adapted influenza A/Puerto Rico/8/34 (PR8) virus strain reveals a similar monomer conformation but a different dimer interface. Further analysis and evaluation shows that the dimer interface observed in the structure of the PR8 NS1 effector domain is likely to be a crystallographic packing effect. A hypothetical model of the intact NS1 dimer is presented. | ||
| - | + | Structure of NS1A effector domain from the influenza A/Udorn/72 virus.,Xia S, Monzingo AF, Robertus JD Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):11-7. Epub 2008 Dec, 18. PMID:19153461<ref>PMID:19153461</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Viruses]] | [[Category: Viruses]] | ||
| - | [[Category: Monzingo, A F | + | [[Category: Monzingo, A F]] |
| - | [[Category: Robertus, J D | + | [[Category: Robertus, J D]] |
| - | [[Category: Xia, S | + | [[Category: Xia, S]] |
[[Category: Host-virus interaction]] | [[Category: Host-virus interaction]] | ||
[[Category: Interferon antiviral system evasion]] | [[Category: Interferon antiviral system evasion]] | ||
Revision as of 13:30, 19 November 2014
Structure of NS1 effector domain
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