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Cathepsin

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 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
=== Procathepsin-B ===
+
* Procathepsin-B
-
[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human<br />
+
**[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human<br />
-
[[1mir]] - rPCTSB (mutant) - rat<br />
+
**[[1mir]] - rPCTSB (mutant) - rat<br />
-
[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br />
+
**[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br />
-
=== Cathepsin-B mature ===
+
* Cathepsin-B mature
-
[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 <br />
+
**[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 <br />
-
[[3mor]] - TbCTSB residues 23-340<br />
+
**[[3mor]] - TbCTSB residues 23-340<br />
-
[[3qsd]], [[3s3q]], [[3s3r]] - CTSB (mutant) residues 87-340+ inhibitor – ''Schistosoma mansoni''<br />
+
**[[3qsd]], [[3s3q]], [[3s3r]] - CTSB (mutant) residues 87-340+ inhibitor – ''Schistosoma mansoni''<br />
-
[[3k9m]] – hMCTSB+stefin A<br />
+
**[[3k9m]] – hMCTSB+stefin A<br />
-
[[3ai8]] – hMCTSB + antibiotic<br />
+
**[[3ai8]] – hMCTSB + antibiotic<br />
-
[[2ipp]], [[1huc]] – hMCTSB<br />
+
**[[2ipp]], [[1huc]] – hMCTSB<br />
-
[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin<br />
+
**[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin<br />
-
[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine<br />
+
**[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine<br />
-
[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor<br />
+
**[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor<br />
-
[[1ito]], [[1qdq]] – bMCTSB +inhibitor<br />
+
**[[1ito]], [[1qdq]] – bMCTSB +inhibitor<br />
-
[[1gmy]] - bMCTSB +dipeptidyl nitrile<br />
+
**[[1gmy]] - bMCTSB +dipeptidyl nitrile<br />
-
[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat<br />
+
**[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat<br />
-
[[1cpj]] - rMCTSB (mutant)<br />
+
**[[1cpj]] - rMCTSB (mutant)<br />
-
[[1cte]] - rMCTSB+pyrimidine inhibitor<br />
+
**[[1cte]] - rMCTSB+pyrimidine inhibitor<br />
-
=== Cathepsin-C mature ===
+
* Cathepsin-C mature
-
[[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2<br />
+
**[[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2<br />
-
[[1jqp]] – rMCTSC<br />
+
**[[1jqp]] – rMCTSC<br />
-
[[1k3b]] – hMCTSC <br />
+
**[[1k3b]] – hMCTSC <br />
-
[[3pdf]] – hMCTSC + inhibitor
+
**[[3pdf]] – hMCTSC + inhibitor
-
=== Cathepsin-D mature ===
+
* Cathepsin-D mature
-
[[1lyw]], [[1lya]] – hMCTSD <br />
+
**[[1lyw]], [[1lya]] – hMCTSD <br />
-
[[1lyb]] - hMCTSD+pepstatin<br />
+
**[[1lyb]] - hMCTSD+pepstatin<br />
-
=== Cathepsin-E mature ===
+
* Cathepsin-E mature
-
[[1tzs]] – hMCTSE+activation peptide from CTSE<br />
+
**[[1tzs]] – hMCTSE+activation peptide from CTSE<br />
-
=== Cathepsin-F mature ===
+
* Cathepsin-F mature
-
[[1m6d]] – hMCTSF+piperidine inhibitor<br />
+
**[[1m6d]] – hMCTSF+piperidine inhibitor<br />
-
=== Cathepsin-G mature ===
+
* Cathepsin-G mature
-
[[1kyn]] – hMCTSG +naphthalene inhibitor<br />
+
**[[1kyn]] – hMCTSG +naphthalene inhibitor<br />
-
[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br />
+
**[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br />
-
[[1t32]] - hMCTSG +piperidine inhibitor
+
**[[1t32]] - hMCTSG +piperidine inhibitor
-
=== Cathepsin-H mature ===
+
* Cathepsin-H mature
-
[[1nb3]], [[1nb5]] – pMCTSH +stefin A – pig<br />
+
**[[1nb3]], [[1nb5]] – pMCTSH +stefin A – pig<br />
-
[[8pch]] - pMCTSH <br />
+
**[[8pch]] - pMCTSH <br />
-
=== Procathepsin-K===
+
* Procathepsin-K
-
[[1by8]], [[7pck]] – hPCTSK<br />
+
**[[1by8]], [[7pck]] – hPCTSK<br />
 +
* Cathepsin-K mature
-
=== Cathepsin-K mature ===
+
**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br />
 +
**[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br />
 +
**[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br />
 +
**[[3c9e]] - hMCTSK + chondroitin-4-sulfate<br />
 +
**[[3kwb]] - hMCTSK (mutant)+dioxo-triazine<br />
 +
**[[3kw9]] - hMCTSK +triazine<br />
 +
**[[1yk8]] - hMCTSK + cyanamide inhibitor<br />
 +
**[[1yt7]] - hMCTSK + ketoamide inhibitor<br />
 +
**[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor<br />
 +
**[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor<br />
 +
**[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]], [[4dmx]], [[4dmy]] - hMCTSK + pyrrolidine inhibitor<br />
 +
**[[1snk]] - hMCTSK + norleucine inhibitor<br />
 +
**[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor<br />
 +
**[[1q6k]] - hMCTSK+carbamate inhibitor<br />
 +
**[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor<br />
 +
**[[1au2]] - hMCTSK+ propanone inhibitor<br />
 +
**[[1atk]] – hMCTSK+guanidine inhibitor<br />
 +
**[[1vsn]], [[4leg]] - hMCTSK+ inhibitor<br />
 +
**[[2ato]] – hMCTSK+myocrisin<br />
 +
**[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br />
 +
**[[1u9w]] - hMCTSK+imidazole inhibitor<br />
 +
**[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br />
 +
**[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br />
-
[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br />
+
*Procathepsin-L
-
[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br />
+
-
[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br />
+
-
[[3c9e]] - hMCTSK + chondroitin-4-sulfate<br />
+
-
[[3kwb]] - hMCTSK (mutant)+dioxo-triazine<br />
+
-
[[3kw9]] - hMCTSK +triazine<br />
+
-
[[1yk8]] - hMCTSK + cyanamide inhibitor<br />
+
-
[[1yt7]] - hMCTSK + ketoamide inhibitor<br />
+
-
[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor<br />
+
-
[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor<br />
+
-
[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]], [[4dmx]], [[4dmy]] - hMCTSK + pyrrolidine inhibitor<br />
+
-
[[1snk]] - hMCTSK + norleucine inhibitor<br />
+
-
[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor<br />
+
-
[[1q6k]] - hMCTSK+carbamate inhibitor<br />
+
-
[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor<br />
+
-
[[1au2]] - hMCTSK+ propanone inhibitor<br />
+
-
[[1atk]] – hMCTSK+guanidine inhibitor<br />
+
-
[[1vsn]], [[4leg]] - hMCTSK+ inhibitor<br />
+
-
[[2ato]] – hMCTSK+myocrisin<br />
+
-
[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br />
+
-
[[1u9w]] - hMCTSK+imidazole inhibitor<br />
+
-
[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br />
+
-
[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br />
+
-
===Procathepsin-L===
+
**[[1cjl]], [[1cs8]] - hPCTS-L (mutant)<br />
 +
**[[3qj3]] - PCTS-L (mutant) – ''Tenebrio molitor''<br />
-
[[1cjl]], [[1cs8]] - hPCTS-L (mutant)<br />
+
* Cathepsin-L mature
-
[[3qj3]] - PCTS-L (mutant) – ''Tenebrio molitor''<br />
+
-
=== Cathepsin-L mature ===
+
**[[3f75]] – MCTSL +CTSL propeptide – ''Toxoplasma gondii''<br />
 +
**[[2p86]] – TbMCTSL +K11002<br />
 +
**[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – ''Trypanosoma cruzi''<br />
 +
**[[4axl]] – hMCTSL catalytic domain<br />
 +
**[[4axm]] – hMCTSL catalytic domain + inhibitor<br />
 +
**[[1mhw]] – hMCTSL +tripeptide<br />
 +
**[[1icf]] – hMCTSL +MHC class II fragment<br />
-
[[3f75]] – MCTSL +CTSL propeptide – ''Toxoplasma gondii''<br />
+
* Procathepsin-L1
-
[[2p86]] – TbMCTSL +K11002<br />
+
-
[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – ''Trypanosoma cruzi''<br />
+
-
[[4axl]] – hMCTSL catalytic domain<br />
+
-
[[4axm]] – hMCTSL catalytic domain + inhibitor<br />
+
-
[[1mhw]] – hMCTSL +tripeptide<br />
+
-
[[1icf]] – hMCTSL +MHC class II fragment<br />
+
-
=== Procathepsin-L1 ===
+
**[[2o6x]] – hPCTSL1 (mutant) – ''Fasciola hepatica''<br />
-
[[2o6x]] – hPCTSL1 (mutant) – ''Fasciola hepatica''<br />
+
* Cathepsin-L1 mature
-
=== Cathepsin-L1 mature ===
+
**[[3iv2]] – hMCTSL1 (mutant) <br />
 +
**[[3k24]] - hMCTSL1 (mutant) +tripeptide<br />
 +
**[[3of8]] - hMCTSL1 + dipeptidyl inhibitor<br />
 +
**[[2xu1]], [[2xu3]], [[2xu4]], [[2xu5]], [[2yj2]], [[2yj8]], [[2yj9]], [[2yjb]], [[2yjc]] - hMCTSL1 catalytic domain (mutant)+nitrile inhibitor<br />
 +
**[[3bc3]], [[3of9]] - hMCTSL1 +inhibitor<br />
 +
**[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor<br />
 +
**[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor<br />
 +
**[[3kse]] – hMCTSL1 (mutant)+stefin
-
[[3iv2]] – hMCTSL1 (mutant) <br />
+
* Cathepsin-L2 mature
-
[[3k24]] - hMCTSL1 (mutant) +tripeptide<br />
+
-
[[3of8]] - hMCTSL1 + dipeptidyl inhibitor<br />
+
-
[[2xu1]], [[2xu3]], [[2xu4]], [[2xu5]], [[2yj2]], [[2yj8]], [[2yj9]], [[2yjb]], [[2yjc]] - hMCTSL1 catalytic domain (mutant)+nitrile inhibitor<br />
+
-
[[3bc3]], [[3of9]] - hMCTSL1 +inhibitor<br />
+
-
[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor<br />
+
-
[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor<br />
+
-
[[3kse]] – hMCTSL1 (mutant)+stefin
+
-
=== Cathepsin-L2 mature ===
+
**[[3h6s]] – hMCTSL2+clitocypin<br />
 +
**[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor<br />
 +
**[[3kfq]] - hMCTSL2 (mutant)+stefin
-
[[3h6s]] – hMCTSL2+clitocypin<br />
+
* Procathepsin-S
-
[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor<br />
+
-
[[3kfq]] - hMCTSL2 (mutant)+stefin
+
-
=== Procathepsin-S ===
+
**[[2c0y]] – hPCTSS (mutant)<br />
-
[[2c0y]] – hPCTSS (mutant)<br />
+
* Cathepsin-S mature
-
=== Cathepsin-S mature ===
+
**[[3n3g]], [[3n4c]] - hMCTSS+ pyrimidine inhibitor<br />
 +
**[[3ovx]] - hMCTSS+ aldehyde inhibitor<br />
 +
**[[3ovz]] - hMCTSS+ ketoamide inhibitor<br />
 +
**[[3kwn]] – hMCTSS (mutant)+ thioether acetamide<br />
 +
**[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor<br />
 +
**[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor<br />
 +
**[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor<br />
 +
**[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br />
 +
**[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor<br />
 +
**[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br />
 +
**[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br />
 +
**[[1glo]] - hMCTSS (mutant)<br />
 +
**[[4bs5]] - mMCTSS+ pyrrolidine inhibitor<br />
 +
**[[4bsq]] - mMCTSS+ morpholine inhibitor<br />
-
[[3n3g]], [[3n4c]] - hMCTSS+ pyrimidine inhibitor<br />
+
* Procathepsin-X
-
[[3ovx]] - hMCTSS+ aldehyde inhibitor<br />
+
-
[[3ovz]] - hMCTSS+ ketoamide inhibitor<br />
+
-
[[3kwn]] – hMCTSS (mutant)+ thioether acetamide<br />
+
-
[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor<br />
+
-
[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor<br />
+
-
[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor<br />
+
-
[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br />
+
-
[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor<br />
+
-
[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br />
+
-
[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br />
+
-
[[1glo]] - hMCTSS (mutant)<br />
+
-
[[4bs5]] - mMCTSS+ pyrrolidine inhibitor<br />
+
-
[[4bsq]] - mMCTSS+ morpholine inhibitor<br />
+
-
=== Procathepsin-X ===
+
**[[1deu]] - hPCTSX<br />
-
[[1deu]] - hPCTSX<br />
+
* Cathepsin-X mature
-
 
+
-
=== Cathepsin-X mature ===
+
-
 
+
-
[[1ef7]] – hMCTSX<br />
+
 +
**[[1ef7]] – hMCTSX<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 13:53, 19 November 2014

Template:STRUCTURE 1pbh

Cathepsin (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS).

3D Structures of Cathepsin

Updated on 19-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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