1ll8
From Proteopedia
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| - | [[Image:1ll8.gif|left|200px]] | + | [[Image:1ll8.gif|left|200px]] |
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| - | '''Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation''' | + | {{Structure |
| + | |PDB= 1ll8 |SIZE=350|CAPTION= <scene name='initialview01'>1ll8</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LL8 is a [ | + | 1LL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL8 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation., Amezcua CA, Harper SM, Rutter J, Gardner KH, Structure. 2002 Oct;10(10):1349-61. PMID:[http:// | + | Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation., Amezcua CA, Harper SM, Rutter J, Gardner KH, Structure. 2002 Oct;10(10):1349-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12377121 12377121] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: pas domain]] | [[Category: pas domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:32:10 2008'' |
Revision as of 10:32, 20 March 2008
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| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation
Overview
PAS domains are sensory modules in signal-transducing proteins that control responses to various environmental stimuli. To examine how those domains can regulate a eukaryotic kinase, we have studied the structure and binding interactions of the N-terminal PAS domain of human PAS kinase using solution NMR methods. While this domain adopts a characteristic PAS fold, two regions are unusually flexible in solution. One of these serves as a portal that allows small organic compounds to enter into the core of the domain, while the other binds and inhibits the kinase domain within the same protein. Structural and functional analyses of point mutants demonstrate that the compound and ligand binding regions are linked, suggesting that the PAS domain serves as a ligand-regulated switch for this eukaryotic signaling system.
About this Structure
1LL8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation., Amezcua CA, Harper SM, Rutter J, Gardner KH, Structure. 2002 Oct;10(10):1349-61. PMID:12377121
Page seeded by OCA on Thu Mar 20 12:32:10 2008
