Molecular Playground/Streptavidin
From Proteopedia
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<StructureSection load='1MEP' size='350' side='right' caption='Structure of Streptavidin (PDB entry [[Ŏ1MEP]])' scene=''> | <StructureSection load='1MEP' size='350' side='right' caption='Structure of Streptavidin (PDB entry [[Ŏ1MEP]])' scene=''> | ||
| - | In the Schiffman | + | In the [http://www.umas.edu/schiffman Schiffman Lab], we fabricate many types of soft materials including electrospun nanofibers, hydrogels, and nanoparticles. In order to tailor each material for wound management and health care applications, it is necessary to functionalize each material with polymers, enzymes, growth factors or antibiotics. To attach such molecules, we attach streptavidin to our material and take advantage of the streptavidin/biotin bond to add agents such as biotinylated antibodies. Biotin can attach to any of the four subunits of streptavidin. The <scene name='56/567309/F/1'>disappearance</scene> of biotin in the complex shows where biotin can bind to streptavidin. |
</StructureSection> | </StructureSection> | ||
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| + | == Other uses in lab == | ||
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| + | In addition to using Streptavidin for attaching antibiotics, we have also start to use Streptavidin to attach Quantum Dots to materials as new sensing devices. These devices should be utilized to determine the presence of specific markers for a variety of applications including the medical field and water purification. | ||
Revision as of 17:53, 19 November 2014
The Use of Streptavidin/Biotin Complex to Functionalize Materials
Streptavidin is a protein best known for its ability to bind to biotin creating the strongest non-covalent interaction in nature.
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
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Other uses in lab
In addition to using Streptavidin for attaching antibiotics, we have also start to use Streptavidin to attach Quantum Dots to materials as new sensing devices. These devices should be utilized to determine the presence of specific markers for a variety of applications including the medical field and water purification.
