Tyler marcinko/sandbox 1

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-	==Tyler's Molecule==	+	== Beta-2-microglobulin==
-	<StructureSection load='1LDS' size='340' side='right' caption='Caption for this structure' scene=''>	+	Beta-2 microglobulin is a 12 kDa protein sub-unit of the class I major histocompatibility complex. In dialysis patients, it has the propensity to form amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA).
-	This is a default text for your page '''Tyler marcinko/sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.	+
-	You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.	+
	== Function ==		== Function ==

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Revision as of 18:10, 19 November 2014

Contents 1 Beta-2-microglobulin 2 Function 3 Disease 4 Aggregation Mechanism 5 B2m Mutations 6 Structural highlights 7 Useful Links 8 References

Beta-2-microglobulin

Beta-2 microglobulin is a 12 kDa protein sub-unit of the class I major histocompatibility complex. In dialysis patients, it has the propensity to form amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA).

Function

Disease

Aggregation Mechanism

Display Nick's Dimer, try to find the tetramer, and the hexameter

B2m Mutations

Structural effects of the various mutations and their oligomers

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>

Useful Links

The Vachet Lab [1]

References