CD3
From Proteopedia
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'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | ||
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==3D structures of CD3== | ==3D structures of CD3== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *CD3 ε chain | |
| - | [[1a81]] – hCD3 ITAM + Syk kinase – human <BR /> | + | **[[1a81]] – hCD3 ITAM + Syk kinase – human <BR /> |
| - | [[2jxb]] – hCD3 domain SH3-1<br /> | + | **[[2jxb]] – hCD3 domain SH3-1<br /> |
| - | [[2k4f]] – mCD3 ITAM – mouse - NMR <BR /> | + | **[[2k4f]] – mCD3 ITAM – mouse - NMR <BR /> |
| - | [[3r08]] – mCD3 extracellular domain + antibody<BR /> | + | **[[3r08]] – mCD3 extracellular domain + antibody<BR /> |
| - | + | *CD3 εγ dimer | |
| - | [[1jbj]] – hCD3 extracellular domain - NMR<BR /> | + | **[[1jbj]] – hCD3 extracellular domain - NMR<BR /> |
| - | [[1sy6]] – hCD3 extracellular domain + antibody<BR /> | + | **[[1sy6]] – hCD3 extracellular domain + antibody<BR /> |
| - | + | *CD3 εδ dimer | |
| - | [[1xiw]] – hCD3 extracellular domain + antibody<BR /> | + | **[[1xiw]] – hCD3 extracellular domain + antibody<BR /> |
| - | [[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR /> | + | **[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR /> |
| - | + | *CD3 ζ chain | |
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| + | **[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR /> | ||
| + | **[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR /> | ||
| + | **[[2hac]] – hCD3 transmembrane domain - NMR<BR /> | ||
| + | }} | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 07:44, 20 November 2014
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3D structures of CD3
Updated on 20-November-2014
