CD4
From Proteopedia
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'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell. | '''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell. | ||
| + | </StructureSection> | ||
==3D structures of CD4== | ==3D structures of CD4== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *CD4 domains | |
| - | [[1cid]] – rCD4 D3 and D4 domains - rat<BR /> | + | **[[1cid]] – rCD4 D3 and D4 domains - rat<BR /> |
| - | [[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 and D2 domains - human<BR /> | + | **[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 and D2 domains - human<BR /> |
| - | [[1cdu]], [[1cdy]] – hCD4 D1 and D2 domains (mutant)<BR /> | + | **[[1cdu]], [[1cdy]] – hCD4 D1 and D2 domains (mutant)<BR /> |
| - | [[1wio]], [[1wip]], [[1wiq]] – hCD4 D1, D2, D3 and D4 domains <BR /> | + | **[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1, D2, D3 and D4 domains <BR /> |
| - | [[2klu]] – hCD4 transmembrane and tail domains - NMR<BR /> | + | **[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR /> |
| - | + | *CD4 binary complex | |
| - | [[1q68]] – hCD4 tail + Lck peptide - NMR<BR /> | + | **[[1q68]] – hCD4 tail + Lck peptide - NMR<BR /> |
| - | [[3b71]] – hCD4 tail + focal adhesion kinase 1<BR /> | + | **[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR /> |
| - | [[3o2d]] – hCD4 D1 and D2 domains + antibody <BR /> | + | **[[3o2d]] – hCD4 D1 and D2 domains + antibody <BR /> |
| - | + | *CD4 ternary complex | |
| - | [[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]] – hCD4 D1 and D2 domains + antibody + gp120<BR /> | + | **[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]] – hCD4 D1 and D2 domains + antibody + gp120<BR /> |
| - | [[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR /> | + | **[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR /> |
| - | [[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR /> | + | **[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR /> |
| - | [[3s4s]] – hCD4 D1 and D2 domains + class II MHC + haemaglutinin peptide<BR /> | + | **[[3s4s]] – hCD4 D1 and D2 domains + class II MHC + haemaglutinin peptide<BR /> |
| - | [[3s5l]] – hCD4 D1 and D2 domains + class II MHC + HA peptide<BR /> | + | **[[3s5l]] – hCD4 D1 and D2 domains + class II MHC + HA peptide<BR /> |
| - | [[3t0e]] – hCD4 D1 and D2 domains + class II MHC + TCR<BR /> | + | **[[3t0e]] – hCD4 D1 and D2 domains + class II MHC + TCR<BR /> |
| + | }} | ||
| + | [[Category: Topic Page]] | ||
Revision as of 07:48, 20 November 2014
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3D structures of CD4
Updated on 20-November-2014
